High-Yield Block D

Question 1

Inhibits initiation of transcription by binding to B subunit of RNA Pol holoenzyme
Used to treat tuberculosis

Answer 1

Rifampicin

Question 2

Inhibits elongation of transcription by interacting with DNA at the transcription initiation complex
Therapeutic uses in cancer chemotherapy

Answer 2

Dactinomycin

Question 3

Inhibits elongation of transcription by interacting with DNA at the transcription initiation complex
Therapeutic uses in cancer chemotherapy

Answer 3

Dactinomycin

Question 4

Any factor, protein, or element independent of the promoter or gene being regulated

Answer 4

Trans-acting element

Question 5

Element that is already there and physically part of the DNA sequence (such as the -10 sequence)

Answer 5

Cis-acting element

Question 6

Potent toxin that binds specifically to RNA Pol II, inhibiting its ability to process along the DNA–>inhibits all transcription

Answer 6

Alpha-amanitin

Question 7

Potent toxin that binds specifically to RNA Pol II, inhibiting its ability to process along the DNA–>inhibits all transcription

Answer 7

Alpha-amanitin

Question 8

Defective B globin gene as a result of incorrect splicing

Prevents creation of mature mRNA

Answer 8

B-thalassemia

Question 9

Autoimmune response to one’s own snRNPs

Answer 9

Systemic lupus erythematosus

Question 10

Stop codons

Answer 10

UGA, UAA, UAG

Question 11

Start codon

Answer 11

AUG