Purine Metabolism Need to Know Flashcards
1
Q
How do sulfonamides inhibit purine synthesis?
A
Interfere with folic acid synthesis
2
Q
How does methotrexate inhibit purine synthesis?
A
Inhibits DHF reductase
3
Q
What is the end product of de novo purine synthesis?
A
IMP
4
Q
What is the rate limiting step?
A
PRPP->5’prosphoribosylamine by glutamine:phosphoribosyl pyrophosphate amidotransferase
5
Q
Where do the N atoms come from?
A
Gly, Asp, Gln
6
Q
Where do the C atoms come from?
A
Gly, CO2, NFTH5
