ETC Inhibitors

Question 1

Amytal & Rotentone

Answer 1

Inhibit electron transfer from FMNH2 to CoQ (after complex I)

Question 2

Antimycin A

Answer 2

Inhibits electron transfer from cyt bc1 to cyt c

binds where UQH2 would dock on complex III

Question 3

CN, CO, & sodium azide

Answer 3

Inhibit electron transfer from cyt a+a3 to oxygen

at complex IV

Question 4

Oligomycin

Answer 4

Binds stalk of Complex V and prevents flow of proteins, blocking ATP synthesis

Question 5

Thermogenin (UCP1)

Answer 5

Causes 90% of respiratory energy to be converted to heat

Question 6

2,4 dinitrophenol & aspirin

Answer 6

Carry charged H+ through hydrophobic environment, relieving the proton gradient

Question 7

Leber hereditary optic neuropathy

Answer 7

blindness arising from mutations in Complex I that impair NADH utilization or e-transfer to CoQ