Leukotriene and Eicosinoid Inhibitors

Question 1

Block mobilization of arachidonic acid by inducing the synthesis of the membrane-associated protein lipocortin, which is a powerful inhibitor of PLA2

Answer 1

Steroid inhibitors

Question 2

Covalently inactivates a key serine on COX-1 and COX-2 by acetylation

Answer 2

Aspirin

Question 3

Powerful anti-inflammatory used as tocolytic agent to delay uterine contractions
Inhibits COX 1/2

Answer 3

Indomethacin

Question 4

Powerful anti-inflammatory and antipyretic restricted to veterinary use

Answer 4

Phenylbutazone

Question 5

Highly selective for COX-2; used as analgesic/anti-inflammatory for osteoarthritis, rheumatoid arthritis, acute pain

Answer 5

Celecoxib (Celebrex)

Question 6

Enolic NSAID highly selective for COX-2 and enhanced bioavailability; used in treatment of joint inflammation; high levels inhibit TxA production

Answer 6

Meloxicam

Question 7

Found in St John’s wort; weak antidepressant; anxiolytic; MAOI; COX-1 inhibitor

Answer 7

Hyperforin