Sos- Cerebral Neoplasias Flashcards
tumor location
meningioma
tumor location
astrocytomas
oligodendroglioma
ganglioglioma
metastatic tumor location
anywhere
tumor location
crosses corpus callosum
glioblastoma
lymphoma
tumor location
ependymoma
central neurocytoma
colloid cyst
tumor location
pituitary adenoma
craniopharyngioma
tumor location
medulloblastoma
ependymoma
pilocytic astrocytoma
hemangioblastoma
metastatic neoplasms
what kind of metastatic neoplasm
melanoma
metastatic hemorrhagic neoplasms
lung
kidney
melanoma
choriocarcinoma
location?
gray-white matter junction
2 types of infiltrating gliomas
astrocytoma
oligodendroglioma
non-infiltrating glioma
gangliomas
chaotic gray matter
metastatic neoplasm
metastatic neoplasm
HMG-45
melanoma stain
metastatic neoplasm
metastatic brain cancer
metastatic brain cancer
astrocytoma
oligodendroglioma
infiltrative lesions
Arise from neoplastic astrocytes and oligodendrocytes within the white matter and infiltrate into gray matter
infiltrative gliomas
In children, where are the most common locations of infiltrative gliomas
brain stem or thalamus
stain for astrocytomas
GFAP+
infiltrating gliomas
astrocytomas
oligodendrogliomas
GFAP+
astrocytes
what glial cell attaches to neurons and blood vessels
astrocytes
normal or glioma
normal
GFAP+
astrocytoma
normal or glioma
glioma
WHO grade II
pleomorphic astrocytes
Astrocytoma
WHO grade III
pleomorphic astrocytes
mitoses (just 1)
anaplastic astrocytoma
WHO grade IV
pleomorphic astrocytes
mitoses
necrosis and/or microvascular proliferation
glioblastoma multiforme (GBM)
in white matter of young adults (30-40 yrs)
>10 yrs of survival
astrocytoma WHO grade II
infiltrating pleomorphic cells with increased cellularity
diffuse astrocytoma WHO grade II
normal or neoplastic
normal
neoplastic or normal
pale=edema
grade II astrocytoma
adult 50 yrs
2-4 yr survival
who grade III
anaplastic astrocytoma
1 mitotic feature
grade III what
anaplastic astrocytoma
normal or neoplastic
neoplastic grade III
50-60 yrs
irregular ring enhancing
1 yr survival
WHO grade IV
glioblastoma multiforme
“butterfly lesion”
glioblastoma multiforme
WHO grade IV
mitotic activity,
endothelial vascular proliferation
and necrosis
glioblastoma multiforme
mitotic activity,
endothelial vascular proliferation
and necrosis
glioblastoma multiforme
pseudopalasading necrosis (neoplastic cells around vessel)
glioblastoma multiforme
necrosis w/ neoplastic cells around
KNOW THIS
glioblastoma multiforme (GBM)
women>men
characteristic loss of chromosomes 1p, 19q
oligodendroglioma
oligodendroglioma has characteristic loss of chromosomes ______
1p, 19q
“fried egg” appearance
oligodendroglioma
Perinuclear halos or fried egg appearance
Delicate capillaries
Calcification
oligodendroglioma
infiltrates the corpus callosum
B-cell type
lymphoma
explosion of lymphocytes
lymphoma
lymphoma
out of the two neoplasms that cross corpus callosum, which one has best prognosis
lymphoma
3 periventricular neoplasms
ependymomas
central neurocytomas
colloid cyst
pt comes in with vision problems
(ACTH, GH, or prolactin producing)
anterior pituitary adenomas
pituitary adenoma (GH producing)
pituitary adenoma (ACTH producing)
oligomenorrhea
amenorrhea
galactorrhea
pituitary adenoma (prolactinoma)
normal pituitary gland
more acidophils
GH adenoma
more basophils
ACTH adenoma
hemorrhage in pituitary adenoma
pituitary apoplexy
Rare benign tumors derived from embryonic pituitary tissue
(HAs, vomiting, vision loss, polyuria)
Craniopharyngioma
calcification
Craniopharyngioma
calcification
Craniopharyngioma
Leftover from developing pituitary area: Rathkes pouch (in b/t anterior and posterior pituitary)
Rathke’s cleft cyst
Mom presents to your pediatric clinic with her 5-year-old child and a chief complaint of her child awakes from sleep with a headache that improves during the day, and vomiting
choroid plexus papilloma
(see hydrocephalus and enlarged ventricles)
rare benign _______tumor
choroid plexus
papillary structures in CSF, what to think
choroid plexus
You examine the brain of a 20-year-old man who was in a MVA
He had a recent history of fainting with a quick recovery
colloid cyst in foramen of monro
colloid cyst
what kills the pt
blood from MVA into ventricular space
Rare benign epidermal cyst arising from the third ventricle near the interventricular foramen
Can cause acute obstruction of CSF flow “drop attacks’ can be fatal
colloid cyst
“drop attacks”
colloid cyst
children
astrocytes
rare
pilocytic astrocytoma of optic n.
pilocytic astrocytoma of optic nerve is associated w/ what
neurofibromatosis type I
child
4th ventricle
ventricle enlargement
crying, wide gait
pilocytic astrocytoma
dilated astrocystic processes
Rosenthal fibers
most common low grade/benign glial tumor in children (see Rosenthal fibers)
Pilocytic Astrocytoma
most common high grade/malignant pediatric CNS neoplasm
medulloblastoma
(3rd ventricle huge and dark and dilated)
child
medulloblastoma
homer-wright rosettes
neuroblastoma in the brain
medulloblastoma
homer wright rosettes
synaptophysin +, chromogranin +
medulloblastoma
found only in ventricles
synaptophysin and chromogranin +
(similar to oligo, but this one is a neuron) “fried egg”
central neurocytoma
difference b/t oligodendroglioma and central neurocytoma
neurocytoma found in ventricles
oligodendroglioma found in neocortex
neurocytoma made from neurons
oligodendroglioma form oligodendocytes