Small DNA Viruses

Question 1

Notable Feature About Parvovirus

Answer 1

Smallest DNA virus, only ss one

Question 2

2 Genera of Parvovirus (& what they need to infect)

Answer 2

Erythrovirus - B19

Dependovirus - “AAV”, need to coinfect with adenoviruses

Question 3

Fifth Disease

Answer 3

From B19 parvovirus, looks like slapped cheek in kids or lacy rash in adults. Biggest problem is aplastic crisis from directly killing of RBC precursors when person also has hemolytic anemia

Question 4

AAV Potential Use

Answer 4

Gene therapy because stably and latently integrate with host cells

Question 5

2 Outcomes of Papilloma/Polyomavirus Infection Depending on Cell Type

Answer 5

Permissive cell: lytic infection

Nonpermissive cell: oncogenic transformation maybe by inhibiting p53 or RB

Question 6

3 Notable Groups HPV Types

Answer 6

Type 1 - plantar wart
2,4 - common wart
6,11 - cancers (papilloma)

Question 7

Adenovirus vs. HPV p53/RB binding comparison

Answer 7

E1A/B vs. E6/7