RNA Resp Viruses Flashcards
4 Kinds of RNA Resp Viruses
Rhinoviruses
Orthomyxoviruses
Coronaviruses
Paramyxoviruses
Rhinovirus Two Kinds of Ags
Knob and pocket
Rhinovirus Most Common R Used
ICAM-1 of Ig Superfamily
3 Orthomyxoviruses and Type of Outbreak of Each
Influenza A (pandemics)
B (local epidemics)
C (not common)
Kind of Cell Orthomyxoviruses Infect
Mitotically active because needs to steal caps from nucleus
Original Antigenic Strain
Only ever make Abs to epitopes shared w/ first influenza you encountered
6 Things Named in Influenza Strain
Type Host of Origin (nothing if human) Geographic Origin Strain Number Year of Isolation Agic Description
2 Neurological Complications with Influenza
Reye’s Syndrome - high mortality encephalopathy/fatty degeneration of liver in children/teens
Guillan Barre Syndrom - temporary paralysis from Ab attack on PNS
4 Antivirals for Influenza
Amantidine and rimantidine: early
Zanamivir and oseltamivir: end
2 Notable Outbreaks Caused by Coronaviruses
SARS and MERS
2 Subfamilies of Paramyxoviruses
Paramyxovirinae and pnemuovirinae
3 Genera in Paramyxovirinae
Paramyxovirus, rubulavirus, and morbillivirus
4 Differences bw Paramyxoviruses and Orthomyxoviruses
Paras are larger, have unsegmented DNA, form inclusion bodies in cytoplasm, and can lack N or both H and N
4 Diseases Caused by Paramyxoviruses
Measles
Mumps
Parainfluenza
Respiratory Syncytial Virus
Croup
Severe laryngotracheobronchitis in babies/toddlers caused by parainfluenza 1 and 2 with hoarseness and barking cough
Main Symptom of Mumps
Swelling of parotid gland only AFTER systemic infection
5 Measles Symptoms
Rash/Koplik's spots Conjunctivitis Cough Coryza Photophobia
Subacute sclerosing panencephalitis
Very fatal viral CNS infection caused by defective measles years after the disease
Difference in Measles/Rubella Rashes
Measles starts on face and covers all torso/face to confluence
Rubella starts on torso and then spreads to concentrate on extremities (not confluent)
Most Notable Congenital Rubella Finding
Cataracts in young children