RNA GI/Neuro Viruses

Question 1

3 Kinds of Picornaviridae

Answer 1

Enterovirus
Rhinovirus
Heparnavirus

Question 2

5 Kinds of Enterovirus

Answer 2

Poliovirus
Coxsackie A&B
Echovirus
Enterovirus

Question 3

4 Differences b/w Rhinoviruses and Enteroviruses

Answer 3

Rhinos are heavier, labile in acidic pH, grow at lower temperature, and not found in intestines

Question 4

3 Kinds of Polio Progression

Answer 4

Inapparent, by far most common
Abortive, have nonspecific illness but doesn’t progress
Frank illness, get CNS involvement

Question 5

Polio Path Through Body

Answer 5

Ingested, then gets lymphatic involvement either through tonsils or Peyer’s patches, then viremia, then CNS involvement

Question 6

Aseptic Meningitis

Answer 6

CSF cultures on regular bacteriologic cultures are sterile

Question 7

3 Clinical Syndromes Associated w/ Coxsackie A/B

Answer 7

Herpangina - sore throat w/ classic vesicular lesions in mouth soft palate
Pleurodynia - devil’s grip, exruciating lower thoracic chest pain
Hand-foot-mouth disease - classic vesicular lesions in these locations

Question 8

Enterovirus Pathway

Answer 8

Ingested, replicate in oropharynx, get into blood and either spread to target organs (different for each) or stopped by Abs. Shit out for spread

Question 9

Rhabdovirus (disease/description, attachment, diagnosis)

Answer 9

Rabies virus with bullet shape
Attaches to AchR via G prot
Can be diagnosed by Negri bodies in infected cells

Question 10

2 Arbovirus Families

Answer 10

Togaviridae (alphaviruses)

Flaviviridae (genus flavivirus)

Question 11

3 Cross Reactive Flaviviridae Groups

Answer 11

SLE
WNV
Japanese Encephalitis

Question 12

WNV Disease Presentation (3)

Answer 12

Usually asymptomatic
Influenza-like WN fever most common
Neurologic illness with older pts

Question 13

WNV Reservoir/Transmission

Answer 13

Usually birds, can be transmitted to humans and horses via mosquitos

Question 14

3 Reoviridae Viruses

Answer 14

Orthoreovirus
Orbivirus/coltivirus
Rotavirus

Question 15

Rotavirus

Answer 15

Resistant FO capsid virus that produces toxins/cytolysis on intestinal epithelium to cause diarrhea and electrolyte loss and shit. #1 cause of diarrheal hospitalizations in infants

Question 16

Notable Structural Feature of Caliciviruses

Answer 16

32 cup shaped surface depressions (calix, cups) on iocsahedral capsid

Question 17

2 Notable Caliciviruses

Answer 17

Noroviruses (like Norwalk virus) and astroviruses

Question 18

Norovirus Disease

Answer 18

Outbreaks of self-limiting gastroenteritis