Large DNA Viruses

Question 1

6 Herpesviruses

Answer 1

Herpes simplex types 1 and 2
Varicella Zoster
Epstein Barr
Cytomegalovirus
Human herpesvirus-6

Question 2

Centripetal vs. Centrifugal Migration

Answer 2

HSV travels from cut to CNS vs. from CNS to epidermis

Question 3

HSV 1 and 2 Preferred Latent Locations

Answer 3

HSV1: Trigeminal ganglia
2: lumbosacral roots

Question 4

Cowdry inclusion bodies

Answer 4

Sites of HSV replication in nuclei of infected cells

Question 5

Acyclovir

Answer 5

Best herpes treatment, chain-terminating guanosine thing that blocks viral thymidine kinase

Question 6

Valcyclovir

Answer 6

Better version for varicella

Question 7

Dideoxycytidine

Answer 7

RT-interfering drug so works well for HIV

Question 8

Chronic Condition linked to EBV and HHV-6

Answer 8

MS

Question 9

Downey Cells

Answer 9

Atypical lymphocytes seen from infectious mononuclosis

Question 10

Burkitt’s Lymphoma

Answer 10

Malignancy connected to young exposure to EBV and continuous malaria Ags. Causes translocation in Bcells

Question 11

Histological Sign of CMV

Answer 11

“Owl’s eye” basophilic nuclear inclusion in urine from epithelial cells shedding

Question 12

Clinical Significance of Vaccinia Virus

Answer 12

Great recombinant virus so we will use it to vaccinate for other diseases