RNA Viral Hemorrhagic Fevers

Question 1

4 RNA Viral Hemorrhagic Families

Answer 1

Arenaviridae
Toga/flaviridae
Bunyaviridae
Filoviridae

Question 2

2 Arenaviruses

Answer 2

Lassa fever virus - W Africa, many subclinical

Junin virus - agricultural in Argentina

Question 3

2 Kinds of Disease from Dengue virus

Answer 3

Dengue fever - common, mild “break bone fever” with “saddleback temperature”
Dengue hemorrhagic fever and Dengue shock syndrome - rarer, usually from Type 2, the dangerous kind

Question 4

Immune Enhancement Theory of Pathogenesis

Answer 4

In DHF/DSS, Abs to 1 strain can bind to another strain, but instead of neutralizing they just bind to macs and allow the virus to infect macs

Question 5

Yellow Fever Hosts

Answer 5

Monkeys, but mosquitos transmit between them and can also transmit from them to us and then between us

Question 6

2 Flaviviruses

Answer 6

Dengue Fever virus and Yellow fever virus

Question 7

3 Bunyavirus Agents (& what spread by)

Answer 7

Crimean-Congo fever virus - ticks
Rift valley fever virus - mosqs and sandflies
Hantavirus - rodents

Question 8

Prime-Boost Vaccine Strategy

Answer 8

Most promising for Ebola: first injection has noninfectious material from microbe to “prime” immune response, second has attenuated carrier virus to boost immune response

Question 9

Bas-Congo Virus

Answer 9

Rhabdovirus that infects like Ebola