IFNs and Antivirals

Question 1

4 Type I and II IFN Differences

Answer 1

pH stable vs. labile
single chain vs. dimer
Almost any infected cells make vs. Ts and NKs make
Induce infected cells to produce antiviral shit vs. activate immune system components

Question 2

IFN Specificity

Answer 2

Species specific, not Ag

Question 3

2 Mechs IFNs Use to Stop Viruses

Answer 3

Activate nucleases that cleave mRNA

Alter initiation factors to freeze mRNA in ribosomes, blocking translation.

Question 4

3 General Kinds of Drug Targets

Answer 4

Cellular activity important for virus but not for cell viability (good)
Activity important for viral replication
Viral activity or structure essential for replication

Question 5

Maraviroc

Answer 5

CCR5 inhibitor for HIV

Question 6

Amatadine/Rimantadine

Answer 6

Influenza antiviral by blocking prot channel to buffer endosome and block acid-mediated fusion of viral envelope

Question 7

Enfuvirtide (Fuzeon)

Answer 7

Antiretroviral that mimics HIV-1 fusion machinery and displaces them, preventing normal fusion

Question 8

Sofosbuvir (Sovaldi)

Answer 8

Ntide analogue inhibitor of HCV RNA dep RNA Pol