Sleep physiology Flashcards

1
Q

What generates the circadian rhythm of sleep?

A

suprachiasmatic nucleus of hypothalamus

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2
Q

What is SCN regulated by?

A

Environment, eg light

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3
Q

What does SCN release?

A

Norepi –> pineal gland

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4
Q

What does the pineal gland release?

A

melatonin

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5
Q

What EEG waveform is present when awake with eyes open?

A

Beta waves - highest frequency, lowest amplitude

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6
Q

What EEG waveform is present when awake with eyes closed?

A

Alpha waves

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7
Q

When are theta EEG waves present?

A

during light sleep, stage N1

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8
Q

When are sleep spindles and K complexes on EEG present?

A

During deeper sleep, stage N2

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9
Q

When are delta waves present? What characterizes delta waves?

A

Delta waves are the lowest frequency, highest amplitude waves. Present during Stage N3, deepest non-REM sleep, aka as slow wave sleep.

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10
Q

What EEG waveforms are present during REM sleep?

A

Beta waves.

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11
Q

During what sleep stage does bruxism occur?

A

Stage N2 (sleep spindles, K complexes)

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12
Q

During what sleep stage does sleep walking, night terrors, and bedwetting occur?

A

Stage N3, delta waves.

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13
Q

During what sleep stage is there loss of motor tones, increased brain oxygen use, and variable pulse and pressure occur?

A

REM sleep (beta waves)

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14
Q

During what sleep stage are there dreaming and night boners?

A

REM sleep

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15
Q

What causes extraocular movements during REM sleep?

A

paramedian pontine reticular formation (conjugate gaze center).

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16
Q

How do alcohol, benzos, and barbituates affect sleep?

A

Decrease REM and delta wave sleep.

17
Q

How does norepi affect sleep?

A

decrease REM sleep

18
Q

How can bedwetting be treated?

A

Oral desmopressin > imipramine.

19
Q

What can be useful for night terrors and sleep walking?

A

Benzos

20
Q

What do the EEG waveforms actually represent?

A

Thalamus cell action potential firing. Single spike/tonic action potentials when awake, burst type groups of action potentials fired during sleep. Mediated by T-type calcium voltage dependent channels.