Ophthalmology - Pathology Flashcards
What visual deficit does cataracts cause?
Blurry/poor vision.
What is the pathogenesis of cataracts?
Painless, often bilateral opacification of lens.
What are the risk factors for cataracts?
Congenital: classic galactosemia, galactokinase deficiency
Acquired: Age. Smoking, etoh, excessive sunlight, prolonged corticosteroid use, DM (sorbitol), trauma, infection.
What visual defect does glaucoma cause?
Progressive peripheral vision loss
What is the pathogenesis of glaucoma?
Optic disc atrophy with cupping - thinning of outer rim of optic nerve head.
What are the two categories of glaucoma?
Open angle and closed/narrow angle
What are the risk factors and characteristics for open angle glaucoma?
Age, AA race, family history. More common in US. Painless.
Primary = cause unclear.
What are the causes of secondary open angle glaucoma?
Blocked trabecular meshwork from WBCs (uveitis), RBCs (vitreous hemorrhage), retinal elements (retinal detachment).
What is primary closed angle glaucoma?
Enlargement or forward movement of lens against central iris (pupil margin) –> obstruction of normal aqueous flow through pupil fluid builds up behind iris, pushing peripheral iris against cornea and impeding flow through trabecular meshwork.
What is secondary closed angle glaucoma?
Secondary—hypoxia from retinal disease (e.g., diabetes mellitus, vein occlusion) induces
vasoproliferation in iris that contracts angle.
What is the presentation of chronic closure glaucoma?
Often asx with damage to optic nerve and peripheral vision.
What is the presentation of acute closed angle glaucoma?
Emergency!! IOP pushes iris forward, angle closes abruptly. Very painful, red eye, sudden vision loss, halos around lights, rock-hard eye, frontal-headache.
What medication is contraindicated in acute closed/narrow angle glaucoma?
Epi. Causes pupillary dilation.
What is the uvea?
Iris, ciliary body, and choroid
What is anterior uveitis vs. posterior uveitis? Associated sx?
Anterior uveitis: Iritis
Posterior uveitis: Choroiditis
- may have hypopyon, conjunctival redness
What is hypopyon?
Accumulation of pus in anterior chamber (associated w/ uveitis).