Skin Part 2: Integument and Barriers to Infection Flashcards
What are used to treat Psoriasis?
Retinoids
Why are retinoids used to treat Psoriasis?
they are anti-proliferative (slows skin growth)
The papillary layer stain _____
pale due to less collagen and elastin
What is the most common GAG in the dermis?
Dermatan Sulfate
What are things you would find in the dermis?
GAGs, Fibroblasts, collagen, elastin, reticular fibers, blood vessels and nerves, small # of macrophages, lymphocytes and mast cells
Dermal Papillae are really prominent in
thick skin
AV Shunts act as a
bypass
Do we see fat in the Dermis?
NO
The hypodermis defining characteristic
the amount of fat
If there is fat it can’t be
DERMIS
In the hypodermis you find
fat
blood vessels and veins
hair follicles (base)
apocrine/eccrine glands
dermatitis
inflammation of the skin
dermatitis is also know as
eczema
“eczema” is applied to a
range of persistent skin conditions
What type of dermatitis is eczema commonly used to describe?
atopic dermatitis
What are the 3 common skin tumors?
squamous cell carcinoma
basal cell carcinoma
melanoma
What types of skin tumor are derived from epithelial cells (keratinocytes)?
squamous cell carcinoma
basal cell carcinoma
What type of skin tumor are derived from melanocytes?
melanoma
squamous cell carcinoma
nest of squamous cells
extend into dermis
eosinic cytoplasm and large nucleus
basal cell carcinoma
small cells
a lot of apoptotic cells
stoma has a lot of GAGs
melanoma
most aggressive form
pagetoid spread of melanocytes
pagetoid spread
“upward spreading” of abnormal cells in the epidermis
First intention healing
clean(surgical) incision
edges can come together
First intention healing steps
- blood clot forms
- neutrophils arrive (3-24hrs)
- basale cells begin mitosis (24-48hrs)
- neutrophils are replaced by macrophages (Day 3-7)
- incision filled with granulation tissue
- continued firboplasia and collagen repair also itching
(week 2) - connective tissue scar, without inflammation (month 2)
