Lymphoid Tissue Flashcards by Kaleigh B

What is the largest lymphatic organ?

spleen (12cm long and 7cm wide)

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Where is the spleen located?

-upper left quadrant of the abdomen
-lower than diaphragm
-ribs 9-11

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What supplies the spleen?

Splenic artery and vein through hilum

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Splenic artery is the ________ branch of the celiac artery

largest

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What drains the splenic vein

inferior mesenteric vein

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Spleens immune functions

-b and T cell replication
-removes aged or defective RBC’s
-recycles Fe and Hb
-hemopoiesis in fetus

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If someone has a splenectomy (spleen removed)

liver and bone marrow will take over function of the spleen

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Spleen lacks

cortex and medulla

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Spleen has

-a capsule
-trabeculae

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white pulp

-appears white/yellow
-both b and T cells

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red pulp

-appears red
-full of blood
-70% of spleen

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pulp cords

-within red pulp
-contain large # of lymphocytes and macrophages

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sinusoids

-in red pulp
-contain mostly blood

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Areas of white pulp in the spleen=

follicular areas
(some have germinal center some do not)

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What is at the center of a follicle in the spleen?

Central Artery

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Within the white pulp is a site of

-antigen presentation
-phagocytosis

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What cells do you find in the white pulp?

macrophage
plasma cell
helper T cells

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Splenic nodules

enlarged germinal center visible to the naked eye

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What is PALS

-periarteriolar lymphatic sheaths
- T cells that surround the central artery
-not well developed in humans

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Trabecular Artery of the spleen

-bloods enters the spleen through these
-branch into the central artery

perpendicular penicillar Artery

-branch off of central artery

open circulation in the spleen

perpendicular penicillin Artery dump blood into pulp cords

closed circulation in the spleen

perpendicular penicillin Artery dump blood into the sinsusiod

sheathed capillaries

-lack endothelial lining
-surrounded by macrophages

What is the path of blood in the spleen

1.enters from the splenic artery 2. trabecular artery 3. central arterioles 4. penicillar arterioles 5.terminal capillaries 6. (open) pulp cords 7. splenic sinusoids 8. trabecular veins 9. splenic veins

Stave Cells

-endothelial -long cells that lie parallel to the long axis of the vessel -helps to filter RBCs

MALT structure

-large collection of lymph nodules -

What is the location of MALT?

-gastrointestinal -respiratory -genital -urinary

Function of MALT

-detect antigens -initiate a response

What are the 3 main Tonsils?

Palatine Lingual Pharyngeal

Waldeyer's Ring

where you find 3 main tonsils -around open of mouth and nose

Function of Waldeyer's Ring

antibody production to common environmental antigens

Tonsils are

-secondary lymphoid structure -a type of MALT

When you have your tonsils removed which one is taken out?

palatine

Where are palatine tonsils located?

in tonsillar crypts

Where is the lingual tonsil located?

back of the tongue

Palatine Tonsil

crypts 1' & 2' follicle no cortex or medulla

Thymus

-Hassal's corpuscle -medula and cortex -most t -cells not B cells

pharyngeal tonsil (adenoids) are located

in nasopharynx

Palatine Tonsil has scattered

lymphoid follices

Tonsillar Crypt

-opening into the tonsil -allows particles in so it can check it

GALT

in gut

BALT

repository track

NALT

pharynx

Dome areas

when lymphoid tissue of GALT projects into the lumen

MALT produces

sIgA

M cells

-in the gut -have a lot of folds on surface -sample Antigens and transfer from gut to lymphoid follicles

When is MALT most abundant?

in childhood (get smaller with age)

Appendix

-has a lot of B cells -may have some role in antigen identification and developing antibodies