Skin Flashcards
what are the three key skin layers
epidermis
dermis
subcut fat
how is palmoplantar skin different
no sebaceous glands
very thick corneal layer
what is bullous pemphigoid
AI vesciculoubullous conditionn in ELDERLY
describe bullous pemphigoid appearance and locatiuon
on flexor surfaces
TENSE bullae
DANGEROUS
Describe aetiology of bullous pemphigoid
AI - driven by IgG and C3, which attack the BM > break off the epidermis from the dermis
they also recruit oesinophils > release elastase> further damage the anchoring proteins
how do you detect bullous pemphigoid
IMMUNOFLUORESCENCE - detects IgG and C3 at dermo-epidermal junction
what is aetiology of pemphigus vulgarius
IgG disease - IgG antibodies attack the protein that keep keratinocytes together > antibodies deposit across the middle of the epidermis
So where is the damage in pemphigus vulgarius
within the keratinocyte layers
what is acantholysis
loss of intracellular connections leading to loss of cohesion betweel keatinocytes - occurs in pemphigus vulgarius
Descibe blisters in pemphigus vulgarius
very FLACCID
rupture easily, leaving red raw surface below
WHat is the aetiology of pemphigus follaceous
IgG deposits superficially, in stratum corneum
Describe the blisters in pemphigus follaceous
very thin, come off very earikly
hardkly ever see them
what is the difference in keratinocyte tunrover for plaque psoriasis
keratinocytes in psoriasis turn over in 7 days
normally they should turn over in 50 days
because of this rapid turnover, epidermis gets thicker
how does lichen planus present
plaques and papules that are slightly purple on wrist and arms
in mouth, present as white lines (Wickam Striae)
what is pyoderma gangrenosum
a form of VASCULITIS, not gangrenous
what does pyoderma gangrenosum presnet as
as an ulcer, not very specific
WHAT DOES SEBORRHOEIC KERATOSIS LOOK LIKE
very common in the elderly
stuck on appearance
what does seborrhoeic keratosis look like under a microscope
Horn cyst
describe a basal cell carcinoma
RODENT. ULCER
pearly, rolled edge with central ulcer
telangectasia
can BCC metastise
NO
what is bowens disease
Pre cancerous stage of skin
SCC in situ
whhaat is SCC
superficial cancer opf the epithelium
very superficial, cells being pushed up
what are the four types of malignant melanoma
superficial spreading - grows sideways
lentigop maligna - slow growing
acral lentiginous - in dark skin people, on palms andf soles
nodular - grows down