Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Path - Histo > Renal > Flashcards

Renal Flashcards

1
Q

what is mode of inheritance of PKD

A

AD or AR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what is presentation of PKD

A

HTN, flank pain, haematuria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what other risk occurs with PKD

A

risk of BERRY NEURYSM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what is acute renal failure

A

RAPID deterioration in renal funvion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what are causes of. AKI

A

pre renal: failure of perfusion
renal: acute tubular injury, acute glomerulomnephritis, thrombotic micrpoangiopathy
post-renal: obstruction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what is the msot common cause of AKI

A

acute tubular injury

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what can cause tubular injury

A

ischaemia
toxins
drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what is acute glomerulonephritis q

A

acute inflammaation of the glomeruli

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what is the KEY HISTO feature of acute glomerulonephritis

A

CRESCENTS on microscopu

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what are causes of acute glomerulonephritis

A

immune complex deposition (IgA)
anti-GBM disease (goodpastures)
Pauci-immune

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is another name of goodpastures disease

A

anti-GBM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what occurs in goodpastures

A

antibodies against C terminal domain of T4 collages

may clross react wiuth albeolar basement membrane, causing pulmonary haemorrhage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what does immunohisto for goodpastures show

A

linear deposition of IgG on glomerular basement membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is thrombotic microangiopathy

A

damaage to endothelium ion glomeruli/arterioles > lead to thrombosis e.g. MAHA, HUS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

list causes of nephrotic syndrome

A

minimal change disease
focal segmental glomerulosclerosdis
membramous glomerulonephritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what occurs histologically in minimal change disease

A

loss of podocytes

17
Q

what occurs histologically in membramous glomerulonephritis

A

thickening of GBM

18
Q

what nodules are pathomnemonic of diabetic nephropathy

A

Kimmelsein-Wilson nodules (stage 3)

19
Q

what is AA amyloidosis associated with

A

chronic inflamm condition

20
Q

What is AL amyloid associated with

A

Ig light chains, so multiple myeloma

21
Q

explain clinical presentation of Alport syndrome

A

X linked dominant

deafness, ocular disease

22
Q

3 primary causes of nephrotic syndrome

A
  1. Minimal change disease
  2. Membranous glomerulonephritis
  3. Focal Segmental glomerulosclerosis
23
Q

Who does minimal change disease occur in

A

children

24
Q

What is seen on electron microscopy in Minimal change

A

loss of podocytes

25
Q

WEhat is seen on microscopy of membranous glomerulonephritis

A

loss of podocytes, spiky subendothelial deposits

26
Q

What is seen on microscopy of Focal Segmental glomerulosclerosis

A

Focal and segmental glomerulosclerosis and scarring

hyalinosis

27
Q

Give two secondary causes of nephrotic syndrome

A

Diabetes

Amyllidosis

28
Q

What is seen on histology of nephrotic syndrome with diabetes

A

Thickened Basement membrane

Kimmelstein wilson nodules aka mesangial matrix

29
Q

list 5 causes of NEPHRITIC syndorme

A
  1. Post strep GN
  2. IgA nephropathy (Berger Disease)
  3. Crescentic (rapidly rogressive) GN
  4. Alport’s (hreditary nephritis)
  5. Benign familial haematuria (thin basement membrane disease)
30
Q

Explain Alport syndrome

A

X linked mutation in T4 collagen

Nephritic syndrome + sensorineural deafness + eye disorder

31
Q

Explain Benign Familial Haematuria (thin basement membrane disease)

A

AD mutation for T4 collagen

Causes diffuse thinnning of GBM

Usually asymptomatic

32
Q

What are the three key causes of asymptomatic haematuria

A

Thin basememnt membrane diseas e
IgA nephropathy
Alport

33
Q

How does nephritic syndrome cause HTN

A

inflammation of glomerular vessels allowing red blood cells to enter the renal tubule; as they enter they are damaged.

The body compensates for inflammation by slowing renal
blood flow

this causes oliguria > water retention >hypertension.

34
Q

what is the timeline for IgA nephropathy after infection

A

only 1-4 days post resp/GI infectioN!!

Path - Histo (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions