Connective tissue

Question 1

features of SLE

Answer 1

SOAP BRAIN MD

Serositis 
Oral ulcers 
Arthritis 
photosensitivity 
Blood (all counts low) 
Renal (proteinuria) 
ANA 
Immunologic (anti-dsDNA) 
Neuro (psych, seizures)
Malar rash 
Discoid rash

Question 2

What does ANA show

Answer 2

shows that the patient has antibodies that bind to nuclear antigen

Non specific

Question 3

What are antibodies in SLE

Answer 3

anti-dsDNA
anti-smith
anti-histone

Question 4

What is the most specific antibody for SLE

Answer 4

anti-smith

Question 5

how do you measure anti dsDNA

Answer 5

incubate patients serum with Crithidia Luciliae (has big mitochondrion with double stranded DNA)
anti-dsDNA will bind to this

Question 6

What does skin histology in SLE look like

Answer 6

Lynmphocytc infiltration of dermis
Vacuolisation
Extravasation or RBC - causes rash

Question 7

what are glomerular capillaries in SLE like

Answer 7

WIRE LOOP capillaries (thickened)

Question 8

what is the endocarditis in SLE

Answer 8

Libman Sacks

NON INFECTRIVE

Question 9

how does Libman sacks present

Answer 9

emboli, heart failure, murmurs

Question 10

What are the features of limited scleroderma

Answer 10

CREST

Calcinosis 
Raynauds 
Eosphageal dysmotolity 
Sclerodactyly 
Telangectasia

Question 11

What is raynauds phenomenon in limited scleroderma

Answer 11

white > blue > red

Question 12

what antibodies are linked to the diffuse scleroderma

Answer 12

DNA topoisomerase

Question 13

What is the difference between limited and diffuse scleroderma

Answer 13

diffuse involves the trunk

Question 14

what is the vascular histology of SLE

Answer 14

intimal proliferation, gives onion skin appearance

Question 15

what is the appearance of ANA on immunofluorescence

Answer 15

speckled

Question 16

what papule are indicative of dermatomyositis

Answer 16

Gottron’s papules (erythematous rash over knuckles)

Question 17

What are skin features of sarcoidosis

Answer 17

Skin - lupus pernio, erythema nodosum

Question 18

what is the hallmark of sarcoidosis

Answer 18

non-caseating granulomatous inflammation

Question 19

what criteria are used for classifying vasculitis based on vessel size

Answer 19

Chapel Hill Criteria

Question 20

what is polyarteritis nodosa

Answer 20

Necrotising artritis

Infiltration by polymorphs, lymphocytes, eosinophils > heals bu fibrosis

Question 21

What is the appearance on angiogram of polyarteritis nodos

Answer 21

Rosary beads appearance

due to the presence of multiple aneurisms

Question 22

What virus is polyarteritis nodosa associated ewith

Answer 22

Hep B

Question 23

Ix for temporal arteritis

Answer 23

ESR

Temporal artery biopsy

Question 24

Tx for temporal arteritis

Answer 24

high done prednisolone

Question 25

Three hallmarks for WegeneRRRs Granulomatosis (with polyangitis)=

Answer 25

RHINO - nosebleeds, sinusitis, saddle nose RESP - haemoptysis, SOB RENAL - haematuria

Question 26

antibody of Wegeners Granulomatosis (with polyangitis)=

Answer 26

c-ANCA

Question 27

Hallmarks of Churg Strauss Syndrome

Answer 27

Eva Churg Strauss Eosinophilia Vasculitis Asthma

Question 28

what its antibody in Churg Strauss Syndrome

Answer 28

pANCA

Question 29

what is pANCA directed against

Answer 29

myeloperoxifdase

Question 30

what is cANCA directed against

Answer 30

Proteinase 3

Question 31

What does NON caseating granuloma mean

Answer 31

A granuloma that is not necrotic

Question 32

describe shared. fts of dermatomyositis and poliomyositis

Answer 32

proximal muscle fatigue (hips, shoulders) Thoracic muscle (lungs dyspnoea, heart arrhyth, oesophagus (dysmotility)- ocular muscle spared

Question 33

what are fts of dermatomyositis only

Answer 33

Gottron papuls | Heliotropic rash