Connective tissue Flashcards
features of SLE
SOAP BRAIN MD
Serositis Oral ulcers Arthritis photosensitivity Blood (all counts low) Renal (proteinuria) ANA Immunologic (anti-dsDNA) Neuro (psych, seizures) Malar rash Discoid rash
What does ANA show
shows that the patient has antibodies that bind to nuclear antigen
Non specific
What are antibodies in SLE
anti-dsDNA
anti-smith
anti-histone
What is the most specific antibody for SLE
anti-smith
how do you measure anti dsDNA
incubate patients serum with Crithidia Luciliae (has big mitochondrion with double stranded DNA)
anti-dsDNA will bind to this
What does skin histology in SLE look like
Lynmphocytc infiltration of dermis
Vacuolisation
Extravasation or RBC - causes rash
what are glomerular capillaries in SLE like
WIRE LOOP capillaries (thickened)
what is the endocarditis in SLE
Libman Sacks
NON INFECTRIVE
how does Libman sacks present
emboli, heart failure, murmurs
What are the features of limited scleroderma
CREST
Calcinosis Raynauds Eosphageal dysmotolity Sclerodactyly Telangectasia
What is raynauds phenomenon in limited scleroderma
white > blue > red
what antibodies are linked to the diffuse scleroderma
DNA topoisomerase
What is the difference between limited and diffuse scleroderma
diffuse involves the trunk
what is the vascular histology of SLE
intimal proliferation, gives onion skin appearance
what is the appearance of ANA on immunofluorescence
speckled