Neurodegeneration

Question 1

What are neyropathological changes that occur with Alzheimers

Answer 1

Extracellulary plaques - amyloid beta
Neurofibrillary tangels
Cerebral amyloid angiopathy
Neuronal loss (cerebral atrophy)

Question 2

what neuropath characterises Parkinson

Answer 2

presence of LEWY BODIES

|&raquo_space; death of dopaminergic cells in subsgtantia nigra > coloratio of substantia nigra is lost

Question 3

what staining is used for parkinsons and what does it shoqw

Answer 3

alpha-synuclein immunostaining

shows lewy bodies, which are accumulatiojns of alpha synuclein

Question 4

what does Pick disease present with as neuropath

Answer 4

Tau positive pick bodies
fronto temporal atrophy
balloon neurons

Question 5

mutations in what proteins cause fronto temporal dementia

Answer 5

tau

progranulin

Question 6

what are symptoms of parkinsons

Answer 6

TRAP 
Tremor 
Rigidity 
Akinesia 
Postural instability 

Later can develop psych features (dementia, halluc, anxiety)

Question 7

what is the cause of MS

Answer 7

AI demyelination of neurons

Question 8

When does MS presnt

Answer 8

20-40 years olf

Question 9

What are symptoms of MS

Answer 9

optic neuritis, poort coord

Question 10

What does MS show on patholgogy

Answer 10

sharp margins of myelin loss