Skin Flashcards
Name the 3 zones of skin
epidermis
dermis
subcuticular/hypodermis
What are the functions of skin?
environmental barrier temperature regulation immunological mechanical support neurosensory metabolic/endocrine glandular secretion
What are the main features of epidermis?
stratified squamous cells
not vascularized
List the layers of epidermis from most internal to external.
basement membrane stratum basale stratum spinosum stratum granulosum (stratum lucidum) stratum corneum
Describe the main characteristics of the stratum basal
columnar/cuboidal stem cells
migrate outwards & keratinize
What are the main general characteristics of cells within the stratum spinosum?
polyhedral
connected via desmosomes
What are the main characteristics of cells in the stratum granulosum?
flattened
keratohyalin & lamelar granules
Describe the general characteristics of the stratum lucidum.
not everywhere
thin & translucent
no nuclear detail
Describe the stratum corneum.
variable # of dead keratinized cells
Describe the keratinization process
keratinocytes increase in size synthesize granules nuclei disintegrate lamellar granules release lipids to extracellular spaces cells flatten
What are langerhans cells? What is their main function? Where are they located?
antigen presenting cells
stratum spinosum
move to dermis for immune function
Describe the basic characteristics & function of melanocytes.
pigmented melanosome granules
stratum basal
melanosomes migrate & are phagocytosed by adjacent keratinocytes
Describe the main characteristics of merkel cells.
stratum basal
vacuolated cytoplasm on dermal side
mechanoreceptors
How does the basement membrane function?
stratum basal attached to BM by hemidesmosomes
structural integrity of skin
List some inclusions within the dermis.
lymphatics blood vessels nerves adnexae (epidermal inclusions within dermis) collagen bundles inflammatory cells
Describe the structure and inclusions of the hypodermis.
adiposites
anchors dermis to muscle
less collagen, more BV
What are dermal papillae?
adhesion between dermis & epidermis
nourishment of epidermis
What are the layers of the dermis?
papillary dermis
reticular dermis