Skeletal System 2 Flashcards
What is ossification (osteogenesis)?
The process of bone tissue formation
What are the two methods of bone formation?
Intramembranous & endochondral ossification
What happens in Intramembranous ossification?
Bone forms within the mesenchyme (embryonic connective tissue) which are arranged in sheets of membranes, and form most cranial bones of the skull
What happens in endochondral ossification?
Bones from within a hyaline cartilage model derived from the mesenchyme and forms most bones
What two factors are necessary for bone growth?
New bone formation & bone remodelling
What is appositional growth?
Bone growth in diameter
What is interstitial growth?
Bone growth in length
What two things happen during interstitial growth?
Growth of epiphyseal plates, and the replacement of cartilage with bone
What are the 4 zones of epiphyseal plates
Nearest to epiphysis, zone of resting, proliferating hypertrophic and calcified cartilage
What is the function of the resting zone?
Contain resting chondocytes that anchor the growth plates to the bone
What is the function of the proliferating zone?
Contain larger chondrocytes that continuously divide to produce new chondrocytes and secrete extra cellular matrix
What is the function of the hypertrophic zone?
Contains columns of large maturing chondrocytes
What is the function of the calcified zone?
Contain dead chondrocytes replaced by bone matrix, and broken up osteoclasts and becomes part of the new diaphysis
What is the epiphyseal line ?
Bony structure of faded cartilage layer which signify the fusing of growth plates.
What causes bone thickening?
Increase in weight & muscular activity
What happens during appositional growth?
Osteoblasts deposit bone in periosteum, while osteoclasts remove bone matrix from the endosteum to enlarge the medullary cavity & prevent high bone weight
What are the two actions involved in bone remodeling?
Bone resorption & bone deposition
What two factors control bone remodeling?
Hormones & mechanical stress
Describe what happens during low levels of blood calcium?
Low blood calcium levels instigate PT cells to increase the generation of AMP which activates more PTH and stimulates osteoclasts to resorb bone to release Ca+2 & kidneys to retain calcium.
What is the function of Calcitonin?
Produced by thyroid gland to decrease Ca+2 in blood
What is the function of leptin?
Formed by adipose tissue inhibit osteoblasts
What factors affect bone growth?
Hormones such as sex, thyroid and GH, Minerals, Vitamins, Adequate diet, & Exercise