skeletal muscle relaxants Flashcards

0
Q

What are the 3 classes of skeletal muscle drugs for the PNS?

A

Depolarizing
Non-depolarizing
Direct acting

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1
Q

What are the 2 nervous systems skeletal muscle relaxants work?

A

PNS (at NMJ at N2 receptors)

CNS (block spinal cord stimulation)

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2
Q

What are the depolarizing drugs for PNS skeletal muscle relaxant?

A

Succinylcholine

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3
Q

What are the non-depolarizing drugs for PNS skeletal muscle relaxants?

A

Tubocurarine
Metocurine
Pipecuronium

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4
Q

How do the centrally acting skeletal muscle relaxants work?

A

Inhibit contraction by blocking conduction within spinal cord by reducing # of impulses that cause contraction

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5
Q

What are the direct acting drugs for PNS muscle skeletal relaxants and the clinical indications?

A

Dantrolene

PO (orally only)
For muscle spasticity, specifically in people with impaired neuromuscular junctions

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6
Q

What do the CNS muscle relaxants NOT do?

A

Interfere with nicotinic II receptors

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7
Q

What are the indications for CNS muscle relaxants?

A

Injured or pulled muscles, spastic muscles or muscle strain

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8
Q

How does succinylcholine work?

A
2 steps:
#1 - attached to N2 receptors and depolarizers 
#2 - then changes the shape of the receptor so it no longer recognizes ACH
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9
Q

What 4 drugs are CNS skeletal muscle relaxants?

A

Baclofen
Cyclobenzaprine (flexeril)
Methocarbamol
Carisoprodol

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10
Q

Why is succinylcholine so specially used in surgery?

A

Short half life

Administered IV only

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11
Q

What are the clinical indications for PNS depolarizing and non-depolarizing drugs?

A
  1. short surgical procedures
  2. longer abdominal surgical procedures
  3. electroconvulsive shock therapy
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12
Q

What are the side effects of PNS depolarizing and non-depolarizing drugs?

A
  1. Hypotension

2. Vasodilation (from histamine release)

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13
Q

What are the adverse effect of PNS depolarizing and non-depolarizing drugs?

A
  1. Bronchospasms
  2. Respiratory Arrest
  3. Arrthymias
  4. Malignant Hyperthermia
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14
Q

What is the NT that stimulates N2 receptors?

A

ACH - acetylcholine

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