Parkinson's Flashcards

1
Q

What are the 3 Parkinson’s drugs used to alleviate symptoms?

A
  1. Bromocriptine
  2. levodopa
  3. carbidopa
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2
Q

How do these drugs work?

A
  1. increase dopamine levels

2. block cholinergic transmission

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3
Q

What it the physiological cause of parkinsons?

A

damage to the dopaminergic neurons so they release less dopamine

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4
Q

What is the effect of less dopamine?

A

There is more Ach activity

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5
Q

What are the 2 nuerotransmitters that help regulate normal acitivty of nerves that control voluntary skeletal muscle movement?

A
  1. Dopamine

2. Ach

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6
Q

What does dopamine do?

A

Inhibit activity and decrease muscle tone

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7
Q

What does Ach do?

A

excitatory stimulation and increase muscle tone

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8
Q

What are the symptoms of Parkinsons?

A
  1. bradykinesia
  2. rigidity
  3. abnormal reflexes
  4. tremors at rest
  5. drooling
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9
Q

Which drug is an anticholinergic?

A

Bromocriptine

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10
Q

What is the MOA of levodopa and carbidopa?

A

inhibit reuptake of dopamine

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