sickle cell Flashcards
1
Q
what type of anaemia does sickle cell tend to be
A
normocytic and normochromic
2
Q
is it autosomal recessive?
A
yes
3
Q
what type of mutation causes it?
A
point mutation causing Hb-> HbS
4
Q
what is the problem with HbS
A
it polymerises at low levels of O2 for too long which distorts RBC membrane meaning that they cant pass through vessels as easily and so can occlude them causing ishaemia and pain
this is a sickle crisis
5
Q
HbAS
A
sickle cell trait
6
Q
HbSS
A
sickle cell anaemia ( 2 abnormal genes)
7
Q
name some precipitants of a sickle cell crisis>
A
hypoxia stress fatigue dehydration infection cold
