Bleeding disorders Flashcards
what are the 4 main things which will prevent the formation of the platelet plug?
vascular problems
reduced number of platelets
poor platelet function
von willebrand factor deficiency
name some vascular causes of the prevention of the formation of the platelet plug
vasculitis- henoch-schonlein purpura,
connective tissue disease- marfans
scurvy
steroids
name some causes of reduced number of platelets preventing the formation of the platelet plug
bone marrow failure
disseminated intravascular coagulation
autoimmune thrombocytopenic puprura
hypersplenism
name some things which can affect platelet function
drugs such as aspirin, NSAIDS
renal failure
what are the main 2 headings which things come under which prevent the formation of the fibrin clot
multiple clotting factor deficiency
single clotting factor deficiency
name some causes of multiple clotting factor deficiency
live failure ( as clotting factors are made in the liver) vit K deficiency warfarin therapy disseminated intravascular coagulation
what is disseminated intravascular coagulation
excessive and inappropriate activation of haemostatic system
what can cause vit K deficiency
poor diet
malabsoprtion- need bile salts
obstructive jaundice- wont produce bile salts
warfarin
haemorrhagic disease of newborn
what can cause disseminated intravascular coagulation
sepsis
obstetric emergencies
malignancy
hypovolaemic shock
what tests do you do to test fibrin clot formation
PT and APTT
name a cause of single clotting factor deficiency
haemophilia
deficiency of VIII
haemophilia A
deficiency of IX
haemophilia B ( christmas disease)
clinical features of haemophilai
recurrent haemarthrosis
recurrent soft tissue bleeds
prolonged bleeding after dental extractions
increased APTT only
