Sex chord stromal tumours

Question 1

Frequency of Sex stromal tumours

Answer 1

3 - 5% of ovarian tumors

Question 2

Peak incidence of sex chord stromal tumours

Answer 2

Peak incidence is around menopause

Question 3

Types of sex cord-stromal tumours

Answer 3

1. Granulosa cell tumour
2. Sertoli-Leydig cell tumour
3. Fibroma

Question 4

Granulosa cell tumour (mechanism of action)

Answer 4

Produces oestrogen leading to precocious puberty if in children or endometrial hyperplasia in adults.

Question 5

Which is the most common type of sex chord stromal tumor?

Answer 5

Granulosa cell tumors

Question 6

Presentation of granulosa cell tumor

Answer 6

1. Large pelvic mass

2. Pain due to torsion / haemorrhage

Question 7

Sertoli-Leydig cell tumors

Answer 7

1. Produces androgens → masculinizing effects

2. Associated with Peutz-Jegher syndrome

Question 8

How does a patient with Sertoli Leydig cell tumor present?

Answer 8

1. Pelvic pain

2. Signs of virilization e.g. amenorrhoea, deep voice and hirsuitism

Question 9

What does granulosa cell tumor produce?

Answer 9

1. Produce inhibin

- often used for follow up surveillance as levels rise prior to clinical detection of recurrence

Question 10

Which is the malignant sex chord stromal tumours?

Answer 10

Granulosa cell tumor

Question 11

Which are the benign sex chord stromal tumours?

Answer 11

1. Sertoli Leydig cell tumors

2. Fibroma