Malignant disease of the ovary

Question 1

Genetic factors associated in ovarian cancer

Answer 1

Mutation of tumor suppressor genes
1. BRCA1 (80%)

2. BRCA2 (15%)
3. HNPCC - hereditary non-polyposis colorectal cancer

Question 2

Lynch syndrome is associated with

Answer 2

1. Mainly associated with endometrial cancer

2. 10% risk of ovarian cancer

Question 3

Factors decreasing risk of ovarian cancer

Answer 3

1. Multi parity
2. Oral contraceptive pill
3. Hysterectomy

Question 4

Factors increasing risk of ovarian cancer

Answer 4

1. Nuliparity
2. Intrauterine device
3. Endometriosis

Question 5

Lifestyle factors which increase the risk of ovarian cancer

Answer 5

1. Cigarette smoking

2. Obesity

Question 6

4 main types of ovarian tumours

Answer 6

1. Surface derived tumors
2. Germ cell tumors
3. Sex cord-stromal tumours
4. Metastasis

Question 7

The most common type of ovarian tumor?

Answer 7

Surface derived/Epithelial tumors

Question 8

Tumors most common adolescent girls?

Answer 8

Germ cell tumors

Question 9

What proportion of tumors are germ cell tumors?

Answer 9

15 - 20%

Question 10

What proportion of tumors are surface derived tumors?

Answer 10

65%

Question 11

What proportion of tumors are Sex chord-stromal tumors?

Answer 11

Represent around 3 -5 % of ovarian tumours

- often produce hormones