Session 4

Question 1

What erythrocyte shape change is associated with extravascular hemolysis?
A. Acanthocyte
b. Schistocyte
c. Ghost cell
d. Spherocyte

Answer 1

Spherocyte

Question 2

What does agglutination indicate?
a. An artifact due to slide preparation
b. Normal finding in cats
c. Alteration of proteins in blood coating red blood cells
Correct response
d. Immune-mediated erythrocyte destruction

Answer 2

Immune-mediated erythrocyte destruction

Question 3

Your patient normally has an HCT of 40%. Immediately following a traumatic event with significant hemorrhage, what do you expect the HCT to be on the hemogram?
Correct response
a. It will remain the same or may increase slightly.
b. It will decrease proportional to the amount of hemorrhage.
c. It will decrease slightly (35%).
d. It will decrease by half (20%).

Answer 3

It will remain the same or may increase slightly.

Question 4

What is a feature of anemia of chronic renal disease?
a. It is considered a form of anemia of chronic disorders.
Correct response
b. It is often a moderate to marked normocytic, normochromic anemia.
c. It is typically a regenerative anemia.
d. It is due to increased erythropoietin production.

Answer 4

It is often a moderate to marked normocytic, normochromic anemia.

Question 5

Your patient has the following findings on the CBC and blood smear:
HCT: Decreased
MCV: Decreased
MCHC: Decreased
Reticulocytes: within reference intervals
Blood smear:
2+ microcytes
1+ hypochromasia
1+ schistocytes
1+ keratocytes
What is most likely cause of the anemia?
a. Extravascular hemolysis
b. Anemia of chronic disease
Correct response
c. Chronic blood loss
d. Acute blood loss

Answer 5

Chronic blood loss

Question 6

Haptoglobin is the molecule that scavenges hemoglobin from the circulation. Which of the following statements is true concerning haptoglobin?
Correct response
a. Haptoglobin binds with hemoglobin to decrease filtration of hemoglobin by the kidney.
b. Haptoglobin destroys hemoglobin in circulation.
c. Haptoglobin is a proteoglycan on the surface of the macrophage that binds hemoglobin.
d. Haptoglobin is produced in the kidney.

Answer 6

Haptoglobin binds with hemoglobin to decrease filtration of hemoglobin by the kidney.

Question 7

An equine patient is presented for colic (a common gastrointestinal ailment in horses). On physical exam, the horse is sweating, has tacky mucous membranes and slightly sunken eyes. On blood work, the hematocrit is 58% (reference interval: 29-37%). What is the most likely cause of the clinical findings and change in hematocrit?
a. Erythrocyte neoplasia causing erythrocytosis
b. Inflammatory disease causing anemia
c. A renal tumor causing erythrocytosis
Correct response
d. Dehydration causing erythrocytosis

Answer 7

Dehydration causing erythrocytosis

Question 8

Which of the following results in an increased MCHC (hyperchromasia)?
a. Reticulocytosis
b. Intravascular hemolysis
c. Red blood cell lysis during blood collection
d. Extravascular hemolysis
Correct response
e. Both B and C
f. Both C and D

Answer 8

Both B and C

Question 9

You have been treating a dog for ongoing pyoderma (skin infections) for the last six months. You run a CBC as part of your routine monitoring bloodwork and note that the dog is mildly anemic and has evidence of inflammation. If your patient has no other comorbidities (other diseases at the same time), what characteristics do you expect the anemia will have?

Answer 9

Normocytic, normochromic, nonregenerative

Question 10

Which is the best answer regarding iron deficiency anemia?
a. It is often associated with thrombocytopenia (decreased platelets).
b. It is due to loss of blood into body cavities.
Correct response
c. It can be regenerative.
d. The erythrocytes are characterized by a decrease in central pallor

Answer 10

It can be regenerative.