Session 16- Humoral Immunity

Question 1

Which antibody isotype is a pentamer?
a. IgA
b. IgE
c. IgG
d. IgM

Answer 1

IgM

Question 2

Which antibody isotype is effective at both neutralization and opsonization?
a. IgA
b. IgE
c. IgG
d. IgM

Answer 2

IgG

Question 3

What is the terminal effector cell of the humoral immune system?
a. Memory T-cell
b. Naïve B-cell
c. Plasma cell
d. Th2 helper T-cell

Answer 3

Plasma Cell

Question 4

Which antibody isotype predominates during the primary immune response, when an individual sees an antigen for the first time?
a. IgA
b. IgE
c. IgG
d. IgM

Answer 4

IgM

Question 5

Which of the following is true concerning the primary and secondary immune responses?
a. The lag period for the secondary immune response is longer than the lag period of the primary response.
b. The production of IgM in the secondary response is greater than that seen in the primary response.
c. The production of IgG is quicker and greater in the secondary response than in the primary response.
d. The primary response produces IgG with greater affinity for the antigen that elicited the response than the IgG produced in the secondary response.

Answer 5

The production of IgG is quicker and greater in the secondary response than in the primary response.

Question 6

Which statement correctly describes opsonization as an antibody effector function?
a. Antibody molecules bind to the cell surface receptors of microbes, preventing them from entering host cells.
b. Antibody molecules coat the outside of a microorganism or foreign particle, making it more likely to be ingested by a macrophage or neutrophil.
c. The ability of an antibody to act as an opsonin is determined by its Fab region.
d. Opsonization triggers destruction of an infected host cell by NK (natural killer) cells.

Answer 6

Antibody molecules coat the outside of a microorganism or foreign particle, making it more likely to be ingested by a macrophage or neutrophil.

Question 7

All of the following are true about B-cells, except:
a. They are antigen presenting cells.
b. They can undergo affinity maturation and isotype switching after activation.
c. Activation of B-cells occurs in the bone marrow.
d. Activation of the B-cell in response to a protein antigen requires three signals.

Answer 7

Activation of B-cells occurs in the bone marrow.

Question 8

Which antibody isotype is a dimer that is secreted onto mucosal surfaces?
a. IgA
b. IgE
c. IgG
d. IgM

Answer 8

IgA

Question 9

Which of the following is trueabout the difference between T-cell dependent and T-cell independent humoral immune responses?
a. Affinity maturation allows B-cells to produce better, stronger antibodies to lipid antigens.
b. Immunologic memory is created after both T-cell dependent and T-cell independent humoral immune responses.
c. Isotype switching is a T-cell dependent process.
d. The activation of a naïve B-cell by a protein antigen is a T-cell independent process requiring three signals.

Answer 9

Isotype switching is a T-cell dependent process.

Question 10

The following are all signals necessary for activation of a naïve B-cell by a protein antigen, except:
a. Binding of the T-cell receptor to the MHC II-antigen complex on the B-cell surface.
b. Switching of the constant region of the immunoglobulin heavy chain to a different isotype class.
c. Production of cytokines by the activated T-cell that further stimulate B-cell proliferation and differentiation.
d. Binding of CD40 on the B-cell to CD40 ligand (CD40L) on the T-cell.

Answer 10

Switching of the constant region of the immunoglobulin heavy chain to a different isotype class.