Session 11- Leukocytes part 2 -PI

Question 1

Increased movement of neutrophils from the bone marrow storage pool to the peripheral blood occurs with?
Corticosteroids/stress and sequestration neutropenia
b. Epinephrine/excitement and granulocytic hypoplasia
c. Acute inflammation and corticosteroids/stress

Answer 1

Acute inflammation and corticosteroids/stress

Question 2

Movement of neutrophils between the circulating and marginal pools in blood is seen in response to:
a. Acute inflammation: marginal to circulating pool
b. Epinephrine: circulating to marginal pool
c. Corticosteroids: marginal to circulating pool
d. Corticosteroids: circulating to marginal pool

Answer 2

Corticosteroids: marginal to circulating pool

Question 3

Altered movement of neutrophils between the peripheral blood and tissues is seen in response to:
a. Epinephrine, increased movement into tissue
b. Corticosteroids/stress, decreased movement into tissue
c. Corticosteroids/stress, increased movement into tissue
d. Acute inflammation, decreased movement into tissue

Answer 3

Corticosteroids/stress, decreased movement into tissue

Question 4

You have a dog with the following leukogram findings on CBC.
WBC count: 32,000/µL (RI: 6,000-17,000)
Neutrophils: 27,300/µL (RI: 3,000-11,400)
Bands: 1,500/µL (RI: 0-300)
How would you characterize the leukogram?
a. Neutrophilia with a leukemoid left shift
b. Neutrophilia with a regenerative (compensated) left shift
c. Neutrophilia with a degenerative (uncompensated) left shift

Answer 4

Neutrophilia with a regenerative (compensated) left shift

Question 4

A pseudoneutropenia can be associated with:
a. Histamine response
b. Epinephrine response
c. Corticosteroid response
d. Marked inflammation

Answer 4

Histamine response

Question 4

What is a common cause of eosinophilia?
Splenic contraction
b. Increased circulating corticosteroids
c. Chronic bacterial infections
d. Allergic reactions

Answer 4

Allergic reactions

Question 5

Five days have passed, and you decide to repeat a CBC on your canine patient from Question 7. You obtain the following results.
WBC count: 23,000/µL (RI: 6,000-17,000)
Neutrophils: 19,200/µL (RI: 3,000-11,400)
Bands: 900/µL (RI: 0-300)
Based on the current state of inflammation, what would you expect to see on a bone marrow sample from this patient?
a. Granulocytic hyperplasia
b. Granulocytic hypoplasia
c. Normal – no changes in the bone marrow compared to a dog with no inflammation

Answer 5

Granulocytic hyperplasia

Question 6

The expected acute inflammatory response in a cow would include:
a. Neutrophilia and lymphocytosis
b. Neutrophilia with a regenerative left shift, similar to that seen in monogastric animals with acute inflammation
c. An exaggerated neutrophilia that mimics a leukemoid response
d. Neutropenia with a left shift

Answer 6

Neutropenia with a left shift

Question 7

What is/are (a) common cause(s) of monocytosis?
a. Chronic inflammation and allergic reaction
b. Corticosteroid response and chronic inflammation
c. Allergic reaction and parasitic infections
d. Nothing, a monocytosis means nothing.

Answer 7

Corticosteroid response and chronic inflammation

Question 7

What is a morphological change in blood neutrophils that is suggestive of inflammation?
a. Decreased cytoplasmic basophilia
b. Loss of cytoplasmic granule staining
c. Dohle bodies
d. Hypersegmentation

Answer 7

Dohle bodies

Question 8

Sparkles is a 6-year-old, female spayed Border Collie presenting with a bacterial pneumonia. You perform a CBC and see that she has neutropenia. What is the most likely mechanism to explain Sparkles’ neutropenia?
a. Sequestration
b. Granulocytic hypoplasia
c. Excessive tissue demand
d. Increased destruction

Answer 8

Excessive tissue demand