Serum proteins

Question 1

difference between plasma and serum

Answer 1

plasma contains blood clotting factors

Question 2

serum proteins can be separated by

Answer 2

electrophoresis

Question 3

dominant protein in serum

Answer 3

albumin

Question 4

proteins in the alpha-1 band

Answer 4

a-Fetoprotein, anti-trypsin, retinol binding protein, transcortin (fart)

Question 5

proteins in alpha-2 band

Answer 5

macroglobulin, ceruloplasmin, haptoglobin

Question 6

proteins in beta band

Answer 6

transferrin, hemopexin, b-lipoprotein (LDL)

Question 7

proteins in gamma band

Answer 7

immunoglobulins

Question 8

charge of albumin at pH 7.4

Answer 8

negative

Question 9

increase in plasma pH makes albumin

Answer 9

more negative.

Question 10

when drugs such as aspirin displace bilirubin from albumin what disease can happen in infants

Answer 10

kernicterus

Question 11

hypoalbuminemia due to poor diet

Answer 11

kwashiorkor

Question 12

inhibitory protein against neutrophil elastase in alveoli

Answer 12

a-1 anti-trypsin

Question 13

low levels of anti-trypsin can lead to

Answer 13

emphysema

Question 14

smoking destroys ______ which is essential for anti-trypsin binding to elastase

Answer 14

methionine residue

Question 15

high maternal AFP can indicate

Answer 15

neural tube defects

Question 16

low maternal AFP can indicate

Answer 16

downs syndrome

Question 17

transports vitamin A from liver to peripheral tissues

Answer 17

retinol binding protein

Question 18

large protease inhibitor

Answer 18

a2 macroglobulin

Question 19

serum protein that changes ferrous ion +2 to ferric ion +3

Answer 19

ceruloplasmin

Question 20

proteinurea with high serum levels of macroglobulin (10x)

Answer 20

nephrotic syndrome

Question 21

copper accumulation in brain, liver, kidney and eyes. Kayser-Fleischer rings in eye

Answer 21

wilsons disease. (low ceruloplasmin)

Question 22

stimulate the synthesis of positive acute phase reactants

Answer 22

cytokines

Question 23

acute phase reactants that deprive microbes of iron to stop growth

Answer 23

ceruloplasmin, haptoglobin

Question 24

acute phase reactant normally not found in serum

Answer 24

C-Reactive Protein

Question 25

first antibody to be produced in response to antigen

Answer 25

IgM

Question 26

antibody secreted in allergic reactions

Answer 26

IgE

Question 27

most common and abundant antibody

Answer 27

IgG

Question 28

antibody found in body secretions and protects body surfaces

Answer 28

IgA

Question 29

antibody that can cross placenta

Answer 29

IgG

Question 30

antibody that is produced after repeated exposure to same antigen

Answer 30

IgG

Question 31

tumor of plasma cells

Answer 31

multiple myeloma

Question 32

antibody associated with liver cirrhosis

Answer 32

IgA (polyclonal gammopathy)

Question 33

disease where the albumin is low and beta and gamma bands are high. (beta-gamma bridge)

Answer 33

cirrhosis