Eicosanoids

Question 1

three types of eicosanoids

Answer 1

prostaglandins, thromboxanes, & leukotrienes

Question 2

all cells produce eicosanoids except

Answer 2

rbc’s

Question 3

arachidonic acid resides at the ____ position on membrane phospholipid ___ and is released by____

Answer 3

C2, PI, phospholipase A2

Question 4

phospholipase A2 cleaves ____ to make _____ & _____

Answer 4

PIP2, arachidonic acid, lyso-PIP2

Question 5

inhibits phospholipase A2

Answer 5

cortisol

Question 6

rate limiting enzyme for prostaglandin synthesis

Answer 6

COX

Question 7

inhibits COX-1 and COX-2

Answer 7

aspirin and NSAIDs

Question 8

COX type that is inducible and specific

Answer 8

COX-2

Question 9

inhibits just COX-2

Answer 9

cortiosteroids

Question 10

involved in platelet aggregation and vasocontriction

Answer 10

Thromboxane A2

Question 11

involved in vasodilation and inhibition of platelet aggregation

Answer 11

Prostacyclin (PGI2)

Question 12

low dose aspirin therapy favors

Answer 12

prostacyclin production.

Question 13

key enzyme for leukotriene synthesis

Answer 13

5-lipoxygenase

Question 14

eicosanoid involved in hypersensitivity and allergic reactions

Answer 14

leukotrienes

Question 15

increases vascular permeability but also causes severe bronchoconstriction and vasoconstriction

Answer 15

LTC, LTE, & LTD (cysteinyl- leukotrienes)