Intro to nitrogen and amino acid metabolism Flashcards
essential amino acids
PVT TIM HALL.
essential amino acid in children that is non essential in adults
arginine
degradation pathway for intracellular proteins that were synthesized by the cell itself
ubiquitin pathway
degrades internalized extracellular proteins
lysosomal pathway
degradation pathway for proteins with short half life
ubiquitin
degradation pathway for proteins with long half life
lysosomal
degradation pathway that doesn’t require ATP
lysosomal
in the ubiquitin pathway the ubiquitin is tagged and attached to which amino acid at the C terminal
glycine
major end product of nitrogen metabolism
urea
end product of purine degradation
uric acid
brush border membrane absorbs amino acids by
secondary active transport
inherited deficiency of COAL transporter
cystinuria
inherited defect in the transport of neutral amino acids like tryptophan
Hartnups
NAD+ deficiency
pellegra
four D’s of Hartnups
dementia, diarrhea, dermatitis, death
treatment of pellegra
niacin
amino acids that feed into tca cycle
glucogenic
ketogenic amino acids
leucine and lysine
enzyme that converts alanine to pyruvate
ALT
transporter of ammonia from the muscle
alanine
enzyme that converts aspartate to OAA
AST
cofactor required for both ALT and AST
PLP ( vit B6 )
enzyme that produces ammonia and is used in some leukemia patients
asparginase
two glucogenic amino acids used in the urea cycle
glutamine and glutamate
renal glutamine is converted back to glutamate via
glutaminase ( releases ammonia )
only pure ketogenic amino acid
lysine
enzymes that release free NH3
glutaminase & glutamate dehydrogenase
