Intro to nitrogen and amino acid metabolism

Question 1

essential amino acids

Answer 1

PVT TIM HALL.

Question 2

essential amino acid in children that is non essential in adults

Answer 2

arginine

Question 3

degradation pathway for intracellular proteins that were synthesized by the cell itself

Answer 3

ubiquitin pathway

Question 4

degrades internalized extracellular proteins

Answer 4

lysosomal pathway

Question 5

degradation pathway for proteins with short half life

Answer 5

ubiquitin

Question 6

degradation pathway for proteins with long half life

Answer 6

lysosomal

Question 7

degradation pathway that doesn’t require ATP

Answer 7

lysosomal

Question 8

in the ubiquitin pathway the ubiquitin is tagged and attached to which amino acid at the C terminal

Answer 8

glycine

Question 9

major end product of nitrogen metabolism

Answer 9

urea

Question 10

end product of purine degradation

Answer 10

uric acid

Question 11

brush border membrane absorbs amino acids by

Answer 11

secondary active transport

Question 12

inherited deficiency of COAL transporter

Answer 12

cystinuria

Question 13

inherited defect in the transport of neutral amino acids like tryptophan

Answer 13

Hartnups

Question 14

NAD+ deficiency

Answer 14

pellegra

Question 15

four D’s of Hartnups

Answer 15

dementia, diarrhea, dermatitis, death

Question 16

treatment of pellegra

Answer 16

niacin

Question 17

amino acids that feed into tca cycle

Answer 17

glucogenic

Question 18

ketogenic amino acids

Answer 18

leucine and lysine

Question 19

enzyme that converts alanine to pyruvate

Answer 19

ALT

Question 20

transporter of ammonia from the muscle

Answer 20

alanine

Question 21

enzyme that converts aspartate to OAA

Answer 21

AST

Question 22

cofactor required for both ALT and AST

Answer 22

PLP ( vit B6 )

Question 23

enzyme that produces ammonia and is used in some leukemia patients

Answer 23

asparginase

Question 24

two glucogenic amino acids used in the urea cycle

Answer 24

glutamine and glutamate

Question 25

renal glutamine is converted back to glutamate via

Answer 25

glutaminase ( releases ammonia )

Question 26

only pure ketogenic amino acid

Answer 26

lysine

Question 27

enzymes that release free NH3

Answer 27

glutaminase & glutamate dehydrogenase