GAGs Flashcards
charge on GAGs
negative
amino sugar used in GAGs
glucosamine or galactosamine
acid sugar used in GAGs
D-glucuronic acid or L-iduronic acid
GAG that doesn’t use acid sugar
keratin sulfate
only GAG not containing sulfate
hyaluronic acid
GAG found in synovial fluid and vitreous humor
hyaluron
most abundant GAG. found in heart valves, bone and cartilage
Chondroitin sulfate
GAG found in cornea, bone and cartilage
keratin sulfate
GAG found in skin, blood vessel and heart valves
dermatin sulfate
only intracellular GAG
heparin
GAG found in basement membrane
heparan sulfate
only GAG not attached to protein (proteoglycan)
hyaluronic acid
proteoglycan in cartilage is made up of
keratin sulfate and chondroitin sulfate
linkage region between GAGs and protein
serine residue followed by xylose-galactose-galactose
keratin sulfate and chondroitin sulfate are attached to core protein via
covalent bonds
how is hyaluronic acids attached to core protein
non covalently
sulfate donor to GAGs
PAPS (phosphoadenosine phosphosulfate) via sulfotransferase
glycosolation of GAGs happens where
golgi
how does heparin regulate thrombosis
prevents coagulation via TFPI or anti-thrombin III
vitamin K analogue that is slower acting than heparin for anti coagulation
warfarin
