GAGs

Question 1

charge on GAGs

Answer 1

negative

Question 2

amino sugar used in GAGs

Answer 2

glucosamine or galactosamine

Question 3

acid sugar used in GAGs

Answer 3

D-glucuronic acid or L-iduronic acid

Question 4

GAG that doesn’t use acid sugar

Answer 4

keratin sulfate

Question 5

only GAG not containing sulfate

Answer 5

hyaluronic acid

Question 6

GAG found in synovial fluid and vitreous humor

Answer 6

hyaluron

Question 7

most abundant GAG. found in heart valves, bone and cartilage

Answer 7

Chondroitin sulfate

Question 8

GAG found in cornea, bone and cartilage

Answer 8

keratin sulfate

Question 9

GAG found in skin, blood vessel and heart valves

Answer 9

dermatin sulfate

Question 10

only intracellular GAG

Answer 10

heparin

Question 11

GAG found in basement membrane

Answer 11

heparan sulfate

Question 12

only GAG not attached to protein (proteoglycan)

Answer 12

hyaluronic acid

Question 13

proteoglycan in cartilage is made up of

Answer 13

keratin sulfate and chondroitin sulfate

Question 14

linkage region between GAGs and protein

Answer 14

serine residue followed by xylose-galactose-galactose

Question 15

keratin sulfate and chondroitin sulfate are attached to core protein via

Answer 15

covalent bonds

Question 16

how is hyaluronic acids attached to core protein

Answer 16

non covalently

Question 17

sulfate donor to GAGs

Answer 17

PAPS (phosphoadenosine phosphosulfate) via sulfotransferase

Question 18

glycosolation of GAGs happens where

Answer 18

golgi

Question 19

how does heparin regulate thrombosis

Answer 19

prevents coagulation via TFPI or anti-thrombin III

Question 20

vitamin K analogue that is slower acting than heparin for anti coagulation

Answer 20

warfarin