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Biochem Post Midterm > Hemostasis > Flashcards

Hemostasis Flashcards

1
Q

primary hemostasis involves

A

platelet plug formation

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2
Q

secondary hemostasis involves

A

blood coagulation

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3
Q

tertiary hemostasis involves

A

dissolution of fibrin clot

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4
Q

platelet glycoprotein that binds to collagen

A

GPIa

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5
Q

platelet glycoprotein that binds to Von willebrand factor

A

GPIb

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6
Q

fibrinogen binds to which platelet glycoprotein

A

GPIIb/GPIIIa

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7
Q

defective GPIb results in

A

Bernard-Soulier syndrome

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8
Q

prevent degradation of factor VIII

A

Vw factor

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9
Q

granule contents that activate other platelets and promote aggregation

A

Calcium and ADP

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10
Q

platelet aggregation is mainly facilitated by

A

fibrinogen

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11
Q

defective GPIIb/GPIIIa leads to

A

thrombasenia of Glanzmann and Naegeli (cannot form platelet plug)

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12
Q

conversion of fibrinogen to fibrin requires

A

thrombin

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13
Q

in the extrinsic pathway, factor VII is activated by

A

tissue factor

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14
Q

in the extrinsic pathway, factor X is activated by

A

tissue factor + factor VIIa + Calcium + platelet phospholipids

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15
Q

in the intrinsic pathway, factor IX is activated by

A

factor XIa

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16
Q

in the intrinsic pathway, factor X is activated by

A

factor IXa + factor VIIIa + Calcium + PL

17
Q

what makes up prothrombinase complex

A

factor Xa + factor Va + Calcium + PL

18
Q

converts prothrombin to thrombin

A

prothrombinase complex

19
Q

coverts soft clot to hard clot

A

factor XIIIa

20
Q

pathway activated by crush injury

A

extrinsic

21
Q

intrinsic pathway defect will have increase in which lab time

A

APTT

22
Q

extrinsic pathway defect will have increase in which lab time

A

Prothrombin time (INR)

23
Q

Vitamin K dependent clotting factors

A

II, VII, IX, X, proteins C & S

24
Q

Vit K is coenzyme for what

A

y-Carboxylase

25
Q

sensitive test for Vitamin K deficiency

A

Prothrombin time (INR)

26
Q

drug that activates plasminogen into plasmin

A

streptokinase or TPA

27
Q

breaks down fibrin into fibrin degradation products

A

plasmin

28
Q

binds to and inhibits factor X and thrombin

A

anti-thrombin III

29
Q

activates anti-thrombin III

A

heparin

Blocks factor 2 & 10

30
Q

block epoxide reductase in liver to prevent regeneration of activated Vit K

A

warfarin

31
Q

deficient in Hemophilia A

A

factor VIII

32
Q

deficient in Hemophilia B

A

factor IX

33
Q

inheritance of hemophilia

A

x linked recessive

34
Q

test to determine effectiveness of platelet plug formation

A

bleeding time

35
Q

low platelet count is called

A

thrombocytopenia

36
Q

disorder with increased clotting time and increased APTT

A

hemophilia

37
Q

Increased in VW disease

A

Aptt, bleeding time

38
Q

protein C & S inactivates factors

A

5 and 8

Biochem Post Midterm (24 decks)

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