Hemostasis

Question 1

primary hemostasis involves

Answer 1

platelet plug formation

Question 2

secondary hemostasis involves

Answer 2

blood coagulation

Question 3

tertiary hemostasis involves

Answer 3

dissolution of fibrin clot

Question 4

platelet glycoprotein that binds to collagen

Answer 4

GPIa

Question 5

platelet glycoprotein that binds to Von willebrand factor

Answer 5

GPIb

Question 6

fibrinogen binds to which platelet glycoprotein

Answer 6

GPIIb/GPIIIa

Question 7

defective GPIb results in

Answer 7

Bernard-Soulier syndrome

Question 8

prevent degradation of factor VIII

Answer 8

Vw factor

Question 9

granule contents that activate other platelets and promote aggregation

Answer 9

Calcium and ADP

Question 10

platelet aggregation is mainly facilitated by

Answer 10

fibrinogen

Question 11

defective GPIIb/GPIIIa leads to

Answer 11

thrombasenia of Glanzmann and Naegeli (cannot form platelet plug)

Question 12

conversion of fibrinogen to fibrin requires

Answer 12

thrombin

Question 13

in the extrinsic pathway, factor VII is activated by

Answer 13

tissue factor

Question 14

in the extrinsic pathway, factor X is activated by

Answer 14

tissue factor + factor VIIa + Calcium + platelet phospholipids

Question 15

in the intrinsic pathway, factor IX is activated by

Answer 15

factor XIa

Question 16

in the intrinsic pathway, factor X is activated by

Answer 16

factor IXa + factor VIIIa + Calcium + PL

Question 17

what makes up prothrombinase complex

Answer 17

factor Xa + factor Va + Calcium + PL

Question 18

converts prothrombin to thrombin

Answer 18

prothrombinase complex

Question 19

coverts soft clot to hard clot

Answer 19

factor XIIIa

Question 20

pathway activated by crush injury

Answer 20

extrinsic

Question 21

intrinsic pathway defect will have increase in which lab time

Answer 21

APTT

Question 22

extrinsic pathway defect will have increase in which lab time

Answer 22

Prothrombin time (INR)

Question 23

Vitamin K dependent clotting factors

Answer 23

II, VII, IX, X, proteins C & S

Question 24

Vit K is coenzyme for what

Answer 24

y-Carboxylase

Question 25

sensitive test for Vitamin K deficiency

Answer 25

Prothrombin time (INR)

Question 26

drug that activates plasminogen into plasmin

Answer 26

streptokinase or TPA

Question 27

breaks down fibrin into fibrin degradation products

Answer 27

plasmin

Question 28

binds to and inhibits factor X and thrombin

Answer 28

anti-thrombin III

Question 29

activates anti-thrombin III

Answer 29

heparin | Blocks factor 2 & 10

Question 30

block epoxide reductase in liver to prevent regeneration of activated Vit K

Answer 30

warfarin

Question 31

deficient in Hemophilia A

Answer 31

factor VIII

Question 32

deficient in Hemophilia B

Answer 32

factor IX

Question 33

inheritance of hemophilia

Answer 33

x linked recessive

Question 34

test to determine effectiveness of platelet plug formation

Answer 34

bleeding time

Question 35

low platelet count is called

Answer 35

thrombocytopenia

Question 36

disorder with increased clotting time and increased APTT

Answer 36

hemophilia

Question 37

Increased in VW disease

Answer 37

Aptt, bleeding time

Question 38

protein C & S inactivates factors

Answer 38

5 and 8