Drugs

Question 0

Irreversible inhibitor of COX, binds to serine residue of active site to favor prostacyclin production and reduce thromboxane formation

Answer 0

ASA (aspirin)

Question 1

target of statins

Answer 1

HMG CoA reductase (competitive inhibitor)

Question 2

inhibitor of thymidylate synthase

Answer 2

5-flurouracil

Question 3

prevents degradation of cAMP, allowing GCPR to have prolonged effects

Answer 3

caffeine or theophylline

Question 4

combines with glycine to form hippuric acid to remove 1 nitrogen from blood

Answer 4

benzoic acid

Question 5

combines with glutamine to form phenylacetyl glutamine to remove 2 nitrogens from blood

Answer 5

phenyl butyrate

Question 6

reduces bacterial urease in the gut

Answer 6

neomycin

Question 7

uses gut flora to lower pH and trap nitrogen in the intestine as NH4

Answer 7

lactulose

Question 8

inhibits prokaryotic dihydrofolate reductase

Answer 8

trimethylprim

Question 9

anticancer drug that inhibits dihydrofolate reductase

Answer 9

MTX

Question 10

blocks THF synthesis in bacteria, can also lead to kernicterus in infants

Answer 10

sulfanomides

Question 11

inhibits IMP dehydrogenase, halting GMP synthesis

Answer 11

mycophenolic acid

Question 12

inhibits cholesterol uptake by inhibiting cholesterol transporter

Answer 12

ezetimibe

Question 13

bile acid sequestering drug

Answer 13

cholestyramine

Question 14

anti cancer drug that inhibits ribonucleotide reductase to prevent formation of dNTPs (converts ADP to dADP)

Answer 14

hydroxyurea

Question 15

inhibits xanthine oxidase to stop production of uric acid

Answer 15

allopurinol

Question 16

increases GSH activity to treat alcoholics who also take tylenol

Answer 16

acetadote

Question 17

used to treat methanol or antifreeze poisoning

Answer 17

fomepizole

Question 18

used to treat acetaminophen overdose

Answer 18

N-acetyl cysteine. (supplies more cysteine for gluthaione production)

Question 19

inhibits acetylaldehyde dehydrogenase to deter alcoholics from drinking

Answer 19

disulfiram

Question 20

stimulates insulin secretion from pancreatic beta cells

Answer 20

sulfonylurea

Question 21

found in egg whites, inhibits biotin absorption

Answer 21

avidin

Question 22

MCAD inhibitor, found in unripe jamican akee fruit

Answer 22

hypoglycin A

Question 24

inhibits DOPA decarboxylase

Answer 24

Carbidopa

Question 25

used to treat pernicious anemia

Answer 25

cyanocobalamin

Question 26

inhibits dihydropteroase synthetase in prokaryotes

Answer 26

sulfonamides

Question 27

can displace bilirubin from albumin

Answer 27

salicylates and sulfonamides

Question 28

inhibits gastric and pancreatic lipases

Answer 28

orlistat