Serotonin, ergot alkaloids, and migraine Flashcards
5-HT is
serotonin
Serontonin/5-HT metabolized by
Monamine Oxidase
90% of 5-HT is found in the
Enterochromaffin cells in the GI tract
Effects of the 5-HT in the nervous system
sleep sensory perception motor activity temp reg VOMITING Chemoreceptor reflex
Effects of 5-HT in the Pulmonary
Small stimulatio of the bronchiolar smooth muscle
Stimulates ACh release from the brochial vagal nerve
Effects of 5-HT in the Cardio
Vasoconstriction except skeletal muscle and heart
Stimulates Platelet Activation
Effects of GI tract
stimulant of smooth muscle
Carcinoid tumors that produce serotonin can cause
diarrhea
Buspirone is a 5-HT1a partial agonist (antagonist in the
anxiolytic
What is a 5-HT2C agonist that was withdrawn because of possibility of toxicity/serotonin syndrome
Dexfenfluramine
5-HT1B/D agonists treat migraines by constricting
cerebral and meningeal vessels (Sumatriptans)
GI Hypermotility 5-HT4 agonists
Cisapride or Tegeserod
Tx: IBD w/ constipation
5-HT receptor Antagonists used to treat what sort of tumors
Carcinoid
What is both a 5-HT Receptor Antagonist as well as an alpha nonselective antagonist?
Phenoxybenzamine
What 5-HT2 antagonist and H1 Receptor Antagonist is used for the treatment of Serotonin Syndrome
Cyprohepatidine
Htn, hyperreflexia, tremor, clonus, hyperthermia, hyperactive bowel sounds, diarrhea, mydriasis, agitation, coma onset within hours
Serotonin Syndrome
Ergot Alkaloids can be of two Varieties
Catecholamine-like or Serotonin Like
Lysergic Acid is a type of
Ergot Alkaloid
What ergot alkaloid can promote dopamine release thus treating prolactinoma
Bromocriptine
Ergot Smooth Muscle stimulant to limit post-partum hemorrhage
Ergonovine
Overuse of non-selective (NSAIDs etc) can cause transformed migraines which indicates
chronic and more painful headaches from sensitization
Migraine-Specific therapy
Ergotamine, Dihydroergotamine (low bioavailability)
Triptans are agonists of the 5-HT
5-HT1D
