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IC > Part II: Psychotic > Flashcards

Part II: Psychotic Flashcards

1
Q

Major Tranquilizers are in contrast to the

A

Benzos and barbs

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2
Q

Neuroleptic refers to the tendency of a drug to produce neuro side effects for example

A

Parkinsonism

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3
Q

Type of symptoms that are common in schizophrenia

A

Negative symptoms more often than positive

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4
Q

Heritability of Schizophrenia

A

50% (identical twin w/ schizophrenia means 50% other twin has it)

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5
Q

Important dopamine pathways important in the brain

A

Mesolimbic

Mesocortical

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6
Q

Neurotransmitter that mediates hallucinogenic effects of schizophrenia

A

5-HT2A and 5-HT2C

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7
Q

NMDA neurotransmitter important in exacerbating schizophrenic symptoms

A

Glutamate (phencyclidine and ketamine)

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8
Q

All antipsychotics are ___________ antagonists

A

D2 dopamine receptor antagonists

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9
Q

What types of symptoms are improved with antipsychotics?

A

Positive symptoms

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10
Q

Extrapyramidal effects of anti-psychotics

A

Dystonia

Akathisia

Parkinsonian symptoms (tremor, rigidity, bradykinesia)

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11
Q

Cardiovascular alterations that can occur with anti-psychotics

A

Prolonged Q-T which can lead to Torsade de Pointes

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12
Q

Endocrine alterations w/ anti-psychotics

A

Increased prolactin release from D2 antagonism

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13
Q

Blurred vision and retinitis pigmentosa can be a side effect of

A

thioridazine

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14
Q

Metabolic syndrome, diabetes can be a side effect of

A

Olanzepine

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15
Q

Dantrolene can treat what syndrome that is a side effect of anti-psychotics

A

Neuroleptic Malignant Syndrome

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16
Q

Long term side effects of anti-psychotics

A

Tardive Dyskinesia (writhing)

Perioral Tremor (rabbit syndrome)

Blood dyscrasias: agranulocytosis w/ clonazapine and some phenothiazines

17
Q

Long Term side effect of clonazapine

A

Blood dyscrasias (agranulocytosis)

18
Q

Antipsychotics potentiate which drugs

A

CNS depressants (classically barbs)

19
Q

What Typical (older) antipsychotics are tricyclic

A

Phenothiazines (Chlorpromazine, fluphenazine, thioridazine)

20
Q

what typical antipsychotic is more selective for dopamine receptors than the typical antipsychotics with the highest incidence of EPS that isn’t a phenothiazine

A

Haloperidol

21
Q

Atypical antipsychotic that does not cause extrapyramidal side effects and antagonist at 5HT2>D2

A

Clozapine (agranulocytosis)

used for tx resistant psychosis (NEVER FIRST LINE), need blood testing

22
Q

Other Newer 5HT2 antagonists w/ EPS at high dose

A

Risperidone 5HT2=D2

Lurasidone 5HT2, D2, 5HT7

23
Q

5HT2 antagonists with less EPS

A

Olanzapine
Quetiapine
Ziprasidone
Aripiprazole

IC (18 decks)

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