Part II: Depression Flashcards
Classes of Antidepressants in order form oldest to newest
MAOIs
TCAs
SSRIs
Misc
Therapeutic effects of antidepressants takes several weeks because
Secondary changes to receptors
Increased BDNF in hippocampus
Cognitive changes
MAOa uses what substrates? MAOb uses what substrate?
MAOa= NE and 5-HT
MAOb= Dopamine
MAOa/b irreversibly inhibitors
Phenelzine
Tranylcypromine
Interactions with MAOis w/ risk even 2 weeks after stopping
SSRIs leading to serotonin syndrome
Food interactions when MAOis interact with tyramine-containing foods (smoked meats) leading to hypertensive crisis
Tricyclic antidepressants that inhibitr the reuptake of NE and/or serotonin and are potent antagonists at various receptors (cholinergic, histaminergic, alpha adrenergic)
Amitriptyline
Nortriptyline
Clomipramine
TCAs side effects
Anticholinergic effects
Orthostatic Hypotension
Arrhythmias
Sexual Dysfunction
Amitryptaline is also a
1A antiarrhythmic
What is the life threatening effect of TCAs
Suicide
SSRIs
Fluoxetine Sertraline Paroxetine citalopram Escitalopram
NE and 5-HT Uptake Inhibitors (SNRIs)
Duloxetine
Venlafaxine
Desvenlafaxine
Levomilmacipran
Selective NE uptake inhibitor
Maprotiline
5-HT uptake Inhibitor
Viladazone
Vortioxetine
Blocking Alpha2 receptors on nerve terminals to increase 5-HT and NE release
Mirtazepine
Inhibition of Dopamine reuptake w/ some CNS stimulations side effects as well as lower incidenceof sexual dysfunction than SSRIs
Bupropion
