Katzung: Tx of Htn Flashcards
What are the most important diuretics for treatment of htn
Thiazides (chlorothalidone lowers mortality, HCTZ) for mild htn
Loop Diuretics for severe htn and htn emergencies
what diuretics are used for the treatment of severe htn or hypertensive emergencies
Loop diuretics
What doses of thiazides are preferred for tx of htn
lower doses than those doses used for diuresis
What are the more effective antihypertensive drugs for African-Americans
Thiazides at low doses
thiazides at a high doses can be used for
congestive heart failure
What are some adverse effects of Thiazides
hypokalemia, hypergycemia, hyperuricemia, hyperlipidemia
What is the only active drug of the ACE inhibitors, with the others being prodrugs
Captopril
How do ACE inhibitors work in decreasing blood pressures for those with mild to moderate hypertension
primarily via decrease in peripheral vascular resistance from reduced angiotensin-induced vasoconstriction
Do ACE inhibitors cause reflex tachycardia?
no because of concurrent baroreceptor resetting/vagal activation
ACE inhibitors are DOC for those with Diabetes, CKD, LVH but not great for which patients
African Americans
ACE inhibitors inhibit aldosterone secretion which can cause what side effect?
Hyperkalemia
ACE inhibitors can cause what adverse effects
angioedema and anaphylaxis
what must you not use ACEIs with?
ARBs (sartan)
Direct Renin Inhibitor (Aliskiren)
What metabolizes Tyramine?
Monamine Oxidase
Calcium channel blockers that are dihydropyridines
Amlodipine, felodipine, isradipine, nicardipine, nifedipine, nimodipine , nisoldipine
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