Seronegative Arthritis

Question 1

What is seronegative arthritis?

Answer 1

Negative rheumatoid factor which may be associated with HLA-B27

Question 2

What are the common signs and symptoms of seronegative arthritis?

Answer 2

Assymetric arthritis
Involvement of axial skeleton (spine)
Enthesitis
Extra articular features (uveitis, IBD)

Question 3

What are the different clinical presentations of seronegative arthritis?

Answer 3

Ankylosing spondylitis
Psoriatic arthritis
Bowel related arthritis (Crohn’s, UC)
Reactive arthritis

Question 4

What is ankylosing spondylitis?

Answer 4

Chronic inflammatory rheumatic disorder with a predilection for axial skeleton and entheses

Question 5

What are the clinical features of ankylosing spondylitis?

Answer 5

Inflammatory back pain
Limitation in movements in antero-posterior as well as lateral planes at lumbar spine
Limitation of chest wall
Bilateral sacroilitis on x-ray

Question 6

What are the different tests for spinal mobility?

Answer 6

Modified Schober
Lateral spinal flexion
Occiput to wall and tragus to wall
Cervical rotation