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Musculoskeletal > Multi-system Autoimmune Disease > Flashcards

Multi-system Autoimmune Disease Flashcards

1
Q

What are some examples of connective tissue diseases?

A

Systemic lupus erythematosus
Scleroderma
Sjorgen’s syndrome
Auto-immune myositis

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2
Q

What are some examples of systemic vasculitis

A

Giant cell arteritis
Granulomatosis polyangitis (Wegener’s)
Microscopic polyangiitis
Eosinophilic granulomatosis poluangiitis

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3
Q

What can mimic autoimmune disease?

A 
Drugs (cocaine, minocyline, PTU) 
Infection (HIV, endocarditis, hepatitis, TB) 
Malignancy (lymphoma) 
Cardiac myxoma 
Cholesterol emboli 
Scurvy
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4
Q

What is the classification criteria for SLE?

A

ANY 4:
Malar rash
Discoid rash
Photosensitivity
Oral ulcers
Arthritis
Serositis
Renal (significant proteinuria or cellular casts)
Neurological (unexplained seizures or psychosis)
Haematological (low WCC, platelets, lymphocytes, haemolytic anaemia)

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5
Q

What is scleroderma?

A

Heterogenous group of conditions linked by the presence of thickened, sclerotic skin lesions

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6
Q

What are the complications of scleroderma?

A

Pulmonary hypertension
Pulmonary fibrosis
Renal crisis
Small bowel bacteria overgrowth

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7
Q

What are the clinical features of Sjogren’s syndrome?

A 
Dry eyes and mouth 
Parotid gland enlargement 
Fatigue 
Fever 
Myalgia 
Arthralgia
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8
Q

What are the complications of Sjogren’s syndrome?

A 
Lymphoma 
Neuropathy 
Purpura 
Interstitial lung disease 
Renal tubular acidosis
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9
Q

What is auto-immune myositis?

A

Muscle weakness, can be symmetrical, diffuse or proximal

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10
Q

What are the clinical features of auto-immune myositis?

A

Gottron’s papules

Heliotrope rash

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11
Q

What are the complications of auto-immune myositis?

A

Cancer

Intersitital lung disease

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12
Q

What are some examples of large vessel vasculitis?

A

Takayasu arteritis

Giant cell arteritis

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13
Q

What are some examples of medium vessel vasculitis?

A

Polyarteritis nodosa

Kawasaki disease

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14
Q

What are some examples of small vessel vasculitis?

A

ANCA-asscociated vasculitis

Immune complex SVV

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15
Q

What is the classification criteria for giant cell arteritis?

A 
3 OF THE FOLLOWING: 
Age at onset >50 
New headache 
Temporal artery tenderness/ reduced pulsation 
ESR>50 
Abnormal temporal biopsy
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16
Q

What is the general treatment for mild auto-immune disease?

A

Hydroxychloroquine

17
Q

What is the general treatment for moderate auto-immune disease?

A

Azathioprine
Methotrexate
Mycophenolate

18
Q

What is the general treatment for severe auto-immune disease?

A

Cyclophosphamide

Rituximab

Musculoskeletal (27 decks)

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