Serology and Lab Testing Flashcards
What are 2 non-specific markers of inflammation?
- ESR
2. CRP
What are 2 non-specific markers for inflammation?
- ESR
2. CRP
ESR and CRP can be used how?
Monitor disease activity
When does ESR rise and in who more often?
Rises with age especially in women
CRP fluctuates ____ than ESR
Quicker
A CRP > ____ indicates inflammation
> 8
Should serologies be used as the sole criterion for diagnosis?
NO
What is Rheumatoid Factor?
IgM antibody that targets Fc portion of IgG
What produces Rheumatoid Factor?
B cells in synovial joints
When is Rheumatoid Factor ALWAYS (+)?
Nodular RA
What is the most specific marker for RA?
Anti-CCP
antibodies to cyclic citrullinated peptides
What gives you the highest specificity for a diagnosis of RA?
RF + Anti-CCP!
What gives you the highest specificity for a diagnosis of RA?
RF + Anti-CCP
RF and Anti-CCP indicate what general processes?
Aggressive disease and joint erosions
Anti-Nuclear Antibody (ANA) often occurs in what disease?
SLE (lupus types)
