Osteoarthritis Flashcards
Define OA
NON-inflammatory arthritis with no systemic symptoms
What are a few risk factors for OA?
Age
Obesity
Occupational hazards
With the pathophysiology of OA, what is lost?
Thinning/loss of hyaline articular cartilage
Describe the type of cartilage that is lost with OA
Type 2 collagen and proteoglycan (aggrecan)
After cartilage is lost, what occurs to the bone with OA?
Subchondral bone thickening (sclerosis) and remodeling
Mild reactive synovitis can also occur. What results and what mediates it?
Mediated by IL-1b and TNF-alpha
= synovial hypertrophy and effusion
What locations are the most commonly affected by OA?
- Cervical and Lumbar spine
- Hips and knees
- 1st CMP (thumb), PIP and DIP joints
- 1st MTP joint
What locations are the most commonly affected by OA?
- Cervical and Lumbar spine
- Hips and Knees
- 1st CMC joint (thumb), PIP, DIP
- 1st MTP joint
Herbedens Nodes
DIP bony prominences
Bouchards Nodes
PIP bony prominences
OA affects what type of joints?
Weight bearing
Often used joints
What type of onset and progression does OA have?
Insidious onset of intermittent symptoms
–> more persistent and severe as time goes on
Describe some symptoms of OA
- Pain worse with activity and relieved by rest
- Crepitus and decreased ROM
- Cool effusion
- Joint instability
Laboratory results with OA?
Usually NORMAL
How does the joint fluid look with OA?
Clear with good viscosity and WBCs < 2000
