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NMSP - Exam 2 > Drugs for Gout > Flashcards

Drugs for Gout Flashcards

1
Q

What drug is the treatment option for Hyperparathyroidism?

A

Cinacalcet

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2
Q

What does Cinacalcet treat?

A

Hyperparathyroidism

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3
Q

What is the MOA for Cinacalcet?

A

Increases PTH receptors sensitivity to calcium in order to decrease PTH secretion

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4
Q

What is the treatment for Osteoarthritis?

A

NOTHING slows or reverses it

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5
Q

If an Osteoarthritis patient wants pain relief, what are some of their options?

A
  • topical NSAID (1% diclofenac gel)

- SNRI (duloxetine)

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6
Q

In the treatment of Osteomyelitis, what should you do first?

A

ID the pathogen

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7
Q

What are some antibiotics (4) that are given for Osteomyelitis and for how long?

A
  • 4-6 weeks
  • Clindamycin
  • Rifampin
  • TMP-SMX
  • Fluoroquinolones
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8
Q

What are 3 NSAIDs that can be used for Gout and what do they inhibit?

A

Naproxen - (-) COX
Indomethacin - (-) COX1
Celecoxib - (-) COX2

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9
Q

What are 2 Xanthine Oxidase (-)’s for Gout?

A

Allopurinol

Febuxostat

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10
Q

What are 2 Xanthine Oxidase (-)s for Gout?

A

Allopurinol

Febuxostat

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11
Q

What are 2 Uricosurics for Gout?

A

Probenecid

Sulfinpyrazone

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12
Q

What are 2 Uricosurics for Gout?

A

Probenecid

Sulfinpyrazone

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13
Q

What are 2 Recombinant Uricase forms to treat Gout?

A

Pegloticase

Rasburicase

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14
Q

What are 2 Recombinant Uricase forms to treat Gout?

A

Pegloticase

Rasburicase

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15
Q

What is 1 microtubule formation disrupter to treat gout?

A

Colchicine

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16
Q

For Acute Gout, what is the order of what should be given?

A

NSAIDS
Colchicine – (-) microtubule formation
Glucocorticoids

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17
Q

For Acute Gout, what is the order of what should be given?

A

NSAIDS
Colchicine – (-) microtubule formation
Glucocorticoids

18
Q

For Established Gout, what are non-pharmacologic things to do?

A

Decrease diet, weight and alcohol

19
Q

For Established Gout, what are the first line agents?

A

Allopurinol

    • Febuxostat
    • Uricosuric
20
Q

For Established Gout, what are the first line agents?

A

Allopurinol

    • Febuxostat
    • Uricosurics
21
Q

What is the last line agent for Established Gout?

A

Pegloticase

22
Q

What is a competitive inhibitor of Xanthine Oxidase?

A

Allopurinol

23
Q

What is a potentially serious adverse effect of Allopurinol and what HLA increases your risk?

A

Hypersensitivity reaction

– HLA-B*5801

24
Q

What are some common (3) side effects of Allopurinol?

A

Skin rash
Gout
Increased liver enzymes

25
Q

What is a NON-competitive inhibitor of Xanthine Oxidase?

A

Febuxostat

26
Q

When should Febuxostat be used?

A

When Allopurinol is not tolerated

27
Q

What is a con of Febuxostat?

A

Expensive

28
Q

What do Xanthine Oxidase (-)’s cause to be excreted?

A

Hypoxanthine and Xanthine

29
Q

What is the MOA for the Uricosurics and what are they?

A
  • Probenecid
  • Sulfinpyrazone
    = organic acids that (-) urate reabsorption&raquo_space; urate secretion
30
Q

Organic acids that (-) urate reabsorption

A

Uricosurics

= Probenecid and Sulfinpyrazone

31
Q

What drugs decrease the plasma concentration of Urate?

A

Probenecid and Sulfinpyrazone

32
Q

What drug can promote urate reabsorption (bad)?

A

Aspirin

33
Q

What drug is attached to Methoxy Polyethylene Glycol?

A

Pegloticase

34
Q

MOA for Pegloticase and Rasburicase?

A

Convert Uric acid to Allantoin (soluble form)

35
Q

What can occur with Pegloticase?

A

Infusion reactions

36
Q

What drug prevents uric acid nephropathy due to tumor lysis syndrome in patients with high risk lymphoma/leukemia?

A

Rasburicase

37
Q

MOA for Probenecid and Sulfinpyrazone?

A

Organic acids that (-) urate reabsorption to decrease urate

38
Q

MOA for Pegloticase and Rasburicase?

A

Convert uric acid to Allantoin (soluble form)

39
Q

What is the MOA for Colchicine?

A

(-) Microtubule formation

40
Q

____ are degraded to uric acid with Gout

A

Purines

NMSP - Exam 2 (29 decks)

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