Drugs for Gout

Question 1

What drug is the treatment option for Hyperparathyroidism?

Answer 1

Cinacalcet

Question 2

What does Cinacalcet treat?

Answer 2

Hyperparathyroidism

Question 3

What is the MOA for Cinacalcet?

Answer 3

Increases PTH receptors sensitivity to calcium in order to decrease PTH secretion

Question 4

What is the treatment for Osteoarthritis?

Answer 4

NOTHING slows or reverses it

Question 5

If an Osteoarthritis patient wants pain relief, what are some of their options?

Answer 5

• topical NSAID (1% diclofenac gel)

- SNRI (duloxetine)

Question 6

In the treatment of Osteomyelitis, what should you do first?

Answer 6

ID the pathogen

Question 7

What are some antibiotics (4) that are given for Osteomyelitis and for how long?

Answer 7

• 4-6 weeks
• Clindamycin
• Rifampin
• TMP-SMX
• Fluoroquinolones

Question 8

What are 3 NSAIDs that can be used for Gout and what do they inhibit?

Answer 8

Naproxen - (-) COX
Indomethacin - (-) COX1
Celecoxib - (-) COX2

Question 9

What are 2 Xanthine Oxidase (-)’s for Gout?

Answer 9

Allopurinol

Febuxostat

Question 10

What are 2 Xanthine Oxidase (-)s for Gout?

Answer 10

Allopurinol

Febuxostat

Question 11

What are 2 Uricosurics for Gout?

Answer 11

Probenecid

Sulfinpyrazone

Question 12

What are 2 Uricosurics for Gout?

Answer 12

Probenecid

Sulfinpyrazone

Question 13

What are 2 Recombinant Uricase forms to treat Gout?

Answer 13

Pegloticase

Rasburicase

Question 14

What are 2 Recombinant Uricase forms to treat Gout?

Answer 14

Pegloticase

Rasburicase

Question 15

What is 1 microtubule formation disrupter to treat gout?

Answer 15

Colchicine

Question 16

For Acute Gout, what is the order of what should be given?

Answer 16

NSAIDS
Colchicine – (-) microtubule formation
Glucocorticoids

Question 17

For Acute Gout, what is the order of what should be given?

Answer 17

NSAIDS
Colchicine – (-) microtubule formation
Glucocorticoids

Question 18

For Established Gout, what are non-pharmacologic things to do?

Answer 18

Decrease diet, weight and alcohol

Question 19

For Established Gout, what are the first line agents?

Answer 19

Allopurinol

• • Febuxostat
• • Uricosuric

Question 20

For Established Gout, what are the first line agents?

Answer 20

Allopurinol

• • Febuxostat
• • Uricosurics

Question 21

What is the last line agent for Established Gout?

Answer 21

Pegloticase

Question 22

What is a competitive inhibitor of Xanthine Oxidase?

Answer 22

Allopurinol

Question 23

What is a potentially serious adverse effect of Allopurinol and what HLA increases your risk?

Answer 23

Hypersensitivity reaction

– HLA-B*5801

Question 24

What are some common (3) side effects of Allopurinol?

Answer 24

Skin rash
Gout
Increased liver enzymes

Question 25

What is a NON-competitive inhibitor of Xanthine Oxidase?

Answer 25

Febuxostat

Question 26

When should Febuxostat be used?

Answer 26

When Allopurinol is not tolerated

Question 27

What is a con of Febuxostat?

Answer 27

Expensive

Question 28

What do Xanthine Oxidase (-)'s cause to be excreted?

Answer 28

Hypoxanthine and Xanthine

Question 29

What is the MOA for the Uricosurics and what are they?

Answer 29

- Probenecid - Sulfinpyrazone = organic acids that (-) urate reabsorption >> urate secretion

Question 30

Organic acids that (-) urate reabsorption

Answer 30

Uricosurics | = Probenecid and Sulfinpyrazone

Question 31

What drugs decrease the plasma concentration of Urate?

Answer 31

Probenecid and Sulfinpyrazone

Question 32

What drug can promote urate reabsorption (bad)?

Answer 32

Aspirin

Question 33

What drug is attached to Methoxy Polyethylene Glycol?

Answer 33

Pegloticase

Question 34

MOA for Pegloticase and Rasburicase?

Answer 34

Convert Uric acid to Allantoin (soluble form)

Question 35

What can occur with Pegloticase?

Answer 35

Infusion reactions

Question 36

What drug prevents uric acid nephropathy due to tumor lysis syndrome in patients with high risk lymphoma/leukemia?

Answer 36

Rasburicase

Question 37

MOA for Probenecid and Sulfinpyrazone?

Answer 37

Organic acids that (-) urate reabsorption to decrease urate

Question 38

MOA for Pegloticase and Rasburicase?

Answer 38

Convert uric acid to Allantoin (soluble form)

Question 39

What is the MOA for Colchicine?

Answer 39

(-) Microtubule formation

Question 40

____ are degraded to uric acid with Gout

Answer 40

Purines