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NMSP - Exam 2 > Drugs for Osteoporosis > Flashcards

Drugs for Osteoporosis Flashcards

1
Q

What are the Bisphosphonates?

A
  • Alendronate and other -dronates

- Zoledronic Acid

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2
Q

What are the Bisphosphonates?

A
  • Alendronate and other -dronates

- Zoledronic Acid

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3
Q

What are the Vitamin D’s?

A
  • Ergocalciferol

- Cholecalciferol

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4
Q

What are the Vitamin D’s?

A
  • Ergocalciferol

- Cholecalciferol

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5
Q

What is the Selective Estrogen Receptor Modulator (SERM)?

A

Raloxifene

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6
Q

What is the Selective Estrogen Receptor Modulator?

A

Raloxifene

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7
Q

What is the RankL (-)?

A

Denosumab

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8
Q

What is the RankL (-)?

A

Denosumab

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9
Q

What is the PTH Hormone?

A

Teriparatide

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10
Q

What is the PTH hormone?

A

Teriparatide

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11
Q

When are parenteral calcium salts given?

A

Severe hypocalcemia

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12
Q

What are possible general side effects of calcium salts?

A

GI, CNS and Renal dysfunctions

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13
Q

What form of Vitamin D/where is Ergocalciferol found?

A

D2 = Plant form

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14
Q

What form of Vitamin D/where is Cholecalciferol found?

A

D3 = sunlight form

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15
Q

What is the MOA for Calcitonin - Salmon?

A

(-) Osteoclasts to decrease bone resorption

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16
Q

What is better about the Calcitonin-Salmon form?

A

Longer half life and more potent than the natural form

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17
Q

When is Calcitonin-Salmon used?

A

For established osteoporosis

18
Q

When is Calcitonin-Salmon NOT used?

A

NOT used for prevention of osteoporosis

19
Q

What is the MOA for the Bisphosphonates and what are they?

A
  • Alendronate and other -dronates and Zolendronic Acid
    = analogs of pyrophosphate
    ==> (-) bone resorption when incorporated into bone
20
Q

What class of drugs are analogs to pyrophosphate and (-) bone resorption by being incorporated into the bone?

A

Bisphosphonates

21
Q

What are the adverse effects (3) of Alendronate and other -dronates?

A
  • Esophagitis
  • Jaw Osteonecrosis
  • Atypical femur fractures
22
Q

What are the adverse effects of Alendronate and other -dronates?

A
  • Esophagitis
  • Jaw Osteonecrosis
  • Atypical femur fractures
23
Q

What should you do to try and avoid the esophagitis that can be associated with Alendronate?

A

Take with water and wait 30 mins before eating or drinking anything else

24
Q

How is Zolendronic Acid given?

A

IV 1X/year

25
Q

What is good about Zolendronic Acid compared to other Bisphosphonates?

A

Avoids GI problems

26
Q

What are the adverse effects (2) of Zolendronic Acid?

A
  • Jaw osteonecrosis

- Kidney damage

27
Q

MOA for Raloxifene

A

Estrogen agonist at bone

Estrogen blocker at breast and uterus

28
Q

What are the adverse effects associated with Raloxifene?

A

Increased risk of DVT, Stroke and Pulmonary Embolism

29
Q

When should you discontinue Raloxifene?

A

Before prolonged inactivity to prevent a DVT, stroke or pulmonary embolism

30
Q

Should you take Raloxifene with pregnancy?

A

NO

31
Q

What is the MOA for Teriparatide?

A

Increases bone formation

32
Q

What drug increases bone formation?

A

Teriparatide

33
Q

When Teriparatide is given in a pulsed fashion, what occurs?

A

Osteoblast activity dominates

34
Q

When Teriparatide is given continuously, what occurs?

A

Osteoclast activity dominates

35
Q

How is Teriparatide given?

A

Once daily by using pre-filled injectors

36
Q

Denosumab (-) RANKL which causes what to occur in the cascade?

A

(-) RANKL
(-) NF-KB
(-) Osteoclast activation
(-) Bone resorption

37
Q

How is Denosumab given?

A

Subcutaneous injection every 6 months

38
Q

What are the adverse effects (3) of Denosumab?

A
  • Delays fracture healing
  • Increases fracture risk
  • Jaw Osteonecrosis
39
Q

What are the 1st line and 2nd line options for Osteoporosis?

A 
1st = Bisphosphonates
2nd = Denosumab
40
Q

What are the 1st and 2nd line agents for Osteoporosis?

A 
1st = Bisphosphonates
2nd = Denosumab

NMSP - Exam 2 (29 decks)

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