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NMSP - Exam 2 > Joint Diseases cont. > Flashcards

Joint Diseases cont. Flashcards

1
Q

Juvenile Idiopathic Arthritis

A

Arthritis before age 16 that persists for at least 6 weeks

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2
Q

What is present and what is absent with Juvenile Idiopathic Arthritis?

A

(+) ANA

(-) Rheumatoid nodules

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3
Q

Ankylosing Spondylitis is associated with what HLA?

A

HLA-B27

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4
Q

Ankylosing Spondylitis is an autoimmune ___ cell response

A

T cell response

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5
Q

Where do the changes occur with Ankylosing Spondylitis?

A

Ligamentous attachments

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6
Q

What are the symptoms of Ankylosing Spondylitis?

A

Low back pain and spinal immobility

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7
Q

Reactive Arthritis is associated with what HLA?

A

HLA-B27

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8
Q

Reactive Arthritis often follows an ___

A

Infection

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9
Q

What are the symptoms of Reactive Arthritis?

A

Conjunctivitis
Nongonoccoal urethritis/cervicitis
Arthritis

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10
Q

What are the symptoms of Reactive Arthritis?

A

Conjunctivitis
Nongonococcal urethritis/cervicitis
Arthritis

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11
Q

The Arthritis with Reactive Arthritis presents how?

A

Waxes and wanes

– Acute onset and Asymmetric

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12
Q

Besides the triad of symptoms with Reactive Arthritis, what else can present?

A

Cardiac valvular disease

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13
Q

Psoriatic Arthritis is associated with what HLA?

A

HLA-B27

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14
Q

What DIP change can be seen with Psoriatic Arthritis?

A

Pencil in cup of DIP

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15
Q

Where else are symptoms common for Psoriatic Arthritis?

A

Nails – thicken, rough and discolor

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16
Q

The seronegative joint diseases are?

A

Psoriatic Arthritis
Reactive Arthritis
Ankylosing Spondylitis

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17
Q

Infectious Arthritis organisms reach the joints how?

A

Hematogenously

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18
Q

What is the most common cause of Infectious Arthritis?

A

Lyme Disease – Borrelia Burgdorferi

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19
Q

What is diagnostic of the most common cause of Infectious Arthritis?

A

(+) anti-Borrelia Antibodies

– lyme disease

20
Q

If lyme disease goes untreated, what does it cause to occur?

A

Migratory Arthritis in large joints and obliterative endarteritis

21
Q

Suppurative Arthritis organisms reach the joints how?

A

Hematogenously

22
Q

If Suppurative Arthritis occurs in neonates, how did it likely arise?

A

Contiguous spread from osteomyelitis

23
Q

In adults, what are the common causes of Suppurative Arthritis?

A

Staph. Aureus
Gonococcus
Salmonella if sickle cell patient

24
Q

In adults, what are the common causes of Suppurative Arthritis?

A

Staph. Aureus
Gonococcus
Salmonella if sickle cell

25
Q

In what gender is Suppurative Arthritis more common?

A

Males

26
Q

Suppurative Arthritis is more common in men, except for when?

A

Sexually active women = Gonococcal Arthritis is more common in women

27
Q

Why is Gonococcal Suppurative Arthritis more common in women?

A

MAC deficient (c5,c6,c7) –> Disseminated Gonococcus

28
Q

What are the symptoms of Suppurative Arthritis?

A

Painful, swollen joint

Fever

29
Q

What lab changes will be present with Suppurative Arthritis?

A

Leukocytosis

Increased ESR

30
Q

IV drug users will likely get Suppurative Arthritis where?

A

Axial joints&raquo_space; knees

31
Q

What is diagnostic of Suppurative Arthritis?

A

Joint aspiration

32
Q

What are 2 crystal induced arthritises?

A

Gout

Calcium Pyrophosphate Crystal Deposition

33
Q

Gout involves transient attacks of acute arthritis due to what?

A

Monosodium Urate Crystallization in and around joints

34
Q

What change will be seen in the plasma with Gout?

A

Hyperuricemia > 6.8

35
Q

In order to have symptomatic Gout, Hyperuricemia > 6.8 in the plasma must be present along with a few of the following?

A 
Age and Male gender 
Alcohol
Obesity
Thiazide diuretics
Lead toxicity
36
Q

What is the hallmark of Gout?

A

Tophi

= Urate crystal aggregates with foreign body giant cells

37
Q

What is the hallmark of Gout?

A

Tophi

= Urate crystal aggregations with foreign body giant cells

38
Q

Gout Acute Arthritis involves pain and warmth where and why?

A

BIG TOE

– low temps help monosodium urate crystalize

39
Q

Gout Chronic Tophaceous Arthritis occurs about 10 years after the Acute. What characterizes it?

A

Urate forms visible deposits in synovium

– Bone erosion too

40
Q

What shape are the monosodium urate crystals with Gout?

A

Needle shaped

41
Q

Calcium Pyrophosphate Crystal Deposition occurs in what joints and what does it look like?

A

Knees

= Chalky white friable deposits

42
Q

Calcium Pyrophosphate Crystal Deposition occurs in what joints and what does it look like?

A

Knees

= Chalky white friable deposits

43
Q

What shape are the Calcium Pyrophosphate crystals?

A

Rhomboid shape

44
Q

What aggregates are seen with Calcium Pyrophosphate Crystal Deposition?

A

Oval blue-purple aggregates

45
Q

What Crystal Induced Arthritis is POSITIVE BIREFRINGENT?

A

Calcium Pyrophosphate Crystal Deposition

– Gout = Negative Birefringent

NMSP - Exam 2 (29 decks)

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