Bone Tumors of Unknown Origin Flashcards
What race/age group gets Ewing Sarcoma Family Tumors?
WHITE people less than 20 yo
What are the histological features of Ewing Sarcomas?
Small blue round cell tumor
– Homer-Wright Rosettes
How do Ewing Sarcomas present?
Painful, tender, warm, swollen mass
– Mimics Infection!
How do Ewing Sarcomas present?
White young person with a painful, tender, warm, swollen mass that mimics an infection
What reaction takes place with Ewing Sarcomas?
Periosteal reaction
How do Ewing Sarcomas look on x-ray?
Onion skin fashion reactive bone
Onion skin reactive bone on x-ray is likely a?
Ewing Sarcoma
Where are Ewing Sarcomas usually located?
Femur (long bones) medullary cavity and invades outer structures
What genetic mutation is present with Ewing Sarcomas?
Fusion translocation: EWSR1-FL11
What genetic mutation is present with Ewing Sarcomas?
Fusion translocation: EWSR1-FL11
What is a good prognostic finding with Ewing Sarcomas?
Increased chemo-induced necrosis
== means the tumor is sensitive to treatment
What is a good prognostic finding with Ewing Sarcomas?
Increased chemo-induced necrosis
Giant Cell Tumor of the bone involves what cells?
Multinucleated OSTEOCLAST-type giant cells with 100+ nuclei
Multinucleated osteoclast-type giant cells with 100+ nuclei is likely?
Giant cell tumor of bone
In the DDX for Giant Cell Tumor of bone, what must be considered?
Brown tumor from hyperparathyroidism
What are the symptoms with Giant Cell Tumor of bone?
Arthritis like symptoms
How do Giant Cell Tumors of bone look on x-ray?
Bulging soft tissue mass with thin shell of reactive bone
How do Giant Cell Tumors of bone look on x-ray?
Bulging soft tissue mass with thin shell of reactive bone
Soft tissue mass with a thin shell of reactive bone with arthritis like symptoms?
Giant cell tumor of bone
When do Aneurysmal Bone Cysts usually present and where?
Adolescence
– vertebral body, femur, tibia
What are the symptoms of Aneurysmal Bone Cysts?
Pain, swelling –> limp and nerve compression
What are the symptoms of Aneurysmal Bone Cysts?
Pain, swelling –> limp and nerve compressions
Central lysis with “eggshell” of reactive bone at the periphery
Aneurysmal bone cyst
How do Aneurysmal Bone Cysts look?
Central lysis with “eggshell” of reactive bone at periphery
What can appear on imaging with Aneurysmal Bone Cysts?
Soap bubble
Some cases of Aneurysmal Bone Cysts appear blue. Why?
Basophilic matrix
This tumor usually presents in the vertebral body, femur or tibia in adolescence
Aneurysmal Bone Cyst
