Seizure Drugs

Question 1

3 Drugs Main Treatment for Partial (Simple and Complex) and Tonic Clonic Seizures

Answer 1

Phenytoin, Carbam, Valproate

Question 2

Tx for Absence

Answer 2

Ethosuximide

Question 3

Tx for Status Epilepticus

Answer 3

Benzos

Question 4

Tx That’s Usually an adjunct for other seizure meds, also maybe for neuralgias/peripheral neuropathies

Answer 4

Gabapentin

Question 5

5 Common SFX For Almost All

Answer 5

Diplopia, sedation, ataxia, nystagmus, dizziness

Question 6

6 Other Phenytoin SFX

Answer 6

Gingival hyperplasia
Hirsutism
Fetal hydantoin syndrome (cleft lip/palate/congenital heart defects, MR)
SLE-like syndrome
Induction of cytochrome P450
SJS

Question 7

3 Teratogens

Answer 7

Phenytoin, Carbam, Valproate (causes spina bifida, need even more folate)

Question 8

Causes SJS (5 anti-seizures and 3 others)

Answer 8

Ethosuximide, Lamotrigine, Carbamazepine, Phenytoin, Phenobarbital
Also sulfonamides, PCNs, and allopurinol

Question 9

5 That Cause Agranulocytosis (not necessarily anti-seiz)

Answer 9

Carbam, cloazapine, colchicine, PTU and methimazole (antithyroids)

Question 10

2 Hepatotoxic

Answer 10

Valproic acid and carbamazepine

Question 11

6 (not necessarily anti-seiz) that Induce Cyt P450

Answer 11

Phenytoin, Rifampin, St Johns Wort, Barbiturates, Griseofulvin, Carbamazepine

Question 12

5 That Block Na Channels

Answer 12

Phenytoin, Carbam, valproate, topiramate, lamotrigine

Question 13

8 That Potentiate GABA

Answer 13

Valproate, phenobarbital, benzos, gabapentin, topiramate, levetiracetam, tiagabine, vigabatrin