Brain Tumors

Question 1

Glioblastoma Multiforme 2 Histo

Answer 1

Astrocytoma so GFAP+

Pseudopalisading

Question 2

Meningioma 2 Histo and Tx

Answer 2

Spindle cells concentrically arranged in whorled pattern
Psamomma bodies
Usually resectable/radiosurgery

Question 3

Hemangioblastoma

Answer 3

Ass’d with VHL, retinal hemorrhages, bilateral RCC, can produce EPO leading to polycythemia

Question 4

Schwannoma Stain result

Answer 4

S-11 positive

Question 5

Oligodendroglio appearance

Answer 5

“Fried egg” (round nuclei with clear cytoplasm)

Like koilocytes and testicular seminoma

Question 6

Pilocytic astrocytoma 2 Histo

Answer 6

GFAP

Rosenthal fibers - eosinophilic, corkscrew fibers

Question 7

Medulloblastoma and Ependymoma Shared Complication

Answer 7

Can compress fourth ventricle causing non-communicating hydrocephalus

Question 8

Medulloblastoma Histo

Answer 8

Homer-Wright rosettes - circumferential small blue cells around central tangle of fibrils

Question 9

Ependymoma Histo (2)

Answer 9

Perivascular rosettes - radial arrangement of tumor cells around vessel.
Rod-shaped blepharoplasts (basal ciliary bodies) found near nucleus

Question 10

2 Tumors Originating from Rathke’s Pouch

Answer 10

Pituitary adenoma and craniopharyngioma

Question 11

Uncal herniation Effects

Answer 11

Compress ipsilateral CN III (blown pupil, down and out gaze), ipsilateral PCA (contralateral homonymous hemianopia), contralateral crus cerebri and Kernohan notch (ipsilateral paresis, a “false localization” sign